Evaluation of Risk Factors Regarding Extubation Failure in Severe Brain Injured Patients.

Severe brain-injured patients require prolonged mechanical ventilation. Weaning these patients from mechanical ventilation is challenging. During neurologic recovery, brain injured patients usually present satisfactory respiratory autonomy. However, the exact timing of extubation is unknown and is frequently delayed because of potential inhalation.

To date, there are no clinical signs available in the current literature that can help the attending physician in the decision-making process of extubation in brain-injured-patients

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Severe Brain Injury Brain Diseases Brain Injuries Central Nervous System Diseases Craniocerebral Trauma Nervous System Diseases Trauma, Nervous System Wounds and Injuries

Age range

15 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Angers University Hospital, Angers, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with brain-injury (traumatic brain injury, subarachnoid haemorrhage, stroke, intracerebral hemorrhage, brain tumour) requiring ≥ 48 hours of mechanical ventilation after admission

Exclusion criteria

Pregnant women
Patient consent withdrawal

Treatment and study plan

Collection of medical data from ICU patients

Other

A code will be applied to each patient included. Medical data such as demography, ISS, clinical exam at time of extubation, extubation failure, tracheotomy, will be collected during ICU stay.

Primary outcomes

Extubation failure

Time frame: In the 48 hours following extubation

Extubation failure is regarded as the need of intubation in the 48 hours following extubation Establish clinial signs before extubation that can predict extubation failure Realization of a systematic clinical examination by the attending physician before performing extubation in severe brain-injured patients

Secondary outcomes

Impact of extubation failure

Time frame: Median 14 days after Intensive Care Unit (ICU) admission
Impact of extubation failure on
- Duration of mechanical ventilation
- Length of ICU stay
- Mortality Describing reasons

Sponsors and collaborators

Lead sponsor

Nantes University Hospital

Other

Registry information

Official study title

Observational Evaluation of Risk Factors Regarding Extubation Failure in Severe Brain-injured Patients

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2014
First posted: Apr 24, 2015
Registry last updated: Sep 13, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed