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Completed

NCT Number: NCT05056532

Evaluation of Respiratory Muscle in Patient With Pulmonary Arterial Hypertension

The aim of the study is that evaluation of basic and accessory respiratory muscles and their relationship of six minute walk test in patient with pulmonary arterial hypertension (PAH)

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Key information

Conditions

Pulmonary Artery Hypertension Dyspnea Familial Primary Pulmonary Hypertension Hypertension, Pulmonary Lung Diseases Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–64 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Istanbul university-cerrahpasa cardiology institute

Istanbul, Haseki, 34096, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients with diagnosis of pulmonary arterial hypertension
  • patients with stabil drug therapy at least three months

Exclusion criteria

  • patients with obstructive and/ or restrictive lung disease comorbidity
  • severe orthopedic and/ or neurological comorbidity
  • patients with heart failure
  • patients with ischemic heart disease
  • uncooperative patients

Treatment and study plan

patient assessment

Diagnostic Test

subjective and objective measurement will be performed in patients with PAH

Primary outcomes

  1. pectoralis muscle strength

    Time frame: 15 minute

    pectoralis muscle strength will be evaluated with hand held dynamometers according to muscle test technique

  2. serratus anterior muscle strength

    Time frame: 15 minutes

    Serratus anterior muscle strength will be evaluated with hand held dynamometers according to muscle test technique

  3. sternocleidomasteoideus muscle strength

    Time frame: 15 minutes

    sternocleidomasteoideus muscle strength will be evaluated with hand held dynamometers according to muscle test technique

  4. Respiratory mouth pressure

    Time frame: 15 minutes

    Respiratory mouth pressure will be measured to determine maximally inspiratory pressure and maximally expiratory pressure according to ATS/ERS guidelines.

Secondary outcomes

  1. Six Minute Walk Test (6MWT)

    Time frame: 30 minutes

    Six minute walk test will be performed to evalute functionally exercise capacity according to ATS/ERS guidelines

  2. Dyspnea assessment

    Time frame: 20 minutes

    London Chest Activity of Daily Living Scale will be used to sensation of dyspnea during activity of daily living.The scale consists of four domains: self-care (four items), domestic (six items), physical (two items) and leisure (three items). In total, the scale consisting of 15 items scored of 0 to 5. 0 means that "I wouldn't do anyway" and 5 means that "Someone else does it for me". Higher values indicate greater limitation due to the dyspnea

Sponsors and collaborators

Lead sponsor

Giresun University

Other

Registry information

Official study title

Evaluation of Primary and Accessory Respiratory Muscles and Their Influence on Exercise Capacity and Dyspnea in Pulmonary Arterial Hypertension

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Sep 24, 2021
Registry last updated
Jun 1, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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