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OpenTrials
Completed

NCT Number: NCT03086590

EVALUATION OF RESPIRATORY MECHANICS AND FUNCTIONALITY IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

To associate a lean mass, peripheral muscle strength, kinematic thoracic-abdominal, respiratory metabolic response, mobility and diaphragmatic thickness, verifying its relation with the obstruction level of COPD

Completed

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Key information

Conditions

Pulmonary Disease, Chronic Obstructive Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases

Age range

21 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Universidade Federal de Pernambuco

Recife, Pernambuco, 50670-901, Brazil

About this study

Individuals with COPD present restriction in their daily lives due to changes and bodily disorders promoted by the disease, such as changes in types of muscle fibers and chronic inflammatory process, causing a low level of physical activity and quality of life, besides being closely Related to the need for hospitalizations and increased mortality. A cross-sectional study with a convenience sample was performed at the Laboratory of Cardiopulmonary Physiotherapy of the Federal University of Pernambuco during the period from December 2016 to February 2018. As measurements of body composition were performed with a bio-balance scale, Evaluation of the peripheral muscle strength will be used the dynamometer, a load cell and electromyography, a kinematic thoracic-abdominal will be measured by optoelectronic plethysmography, a respiratory metabolic response will be verified during the 6-minute walk test using the gas analyzer, and for evaluation of mobility and diaphragmatic thickness are used on ultrasound associated with pneumotachograph.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Young adults, adults and elderly subjects

Exclusion criteria

  • Others respiratory diseases;
  • Heart diseases;
  • Those who are in some previous training program or rehabilitation;

Treatment and study plan

Primary outcomes

  1. Fat-free mass

    Time frame: Baseline

    Mass of the human body disregarding fat.

  2. Quadriceps Force

    Time frame: Baseline

    Quadriceps muscle strength measured during maximum voluntary contraction.

  3. Handgrip strength

    Time frame: Baseline

    Maximum voluntary manual holding force.

  4. Total chest wall volume

    Time frame: Baseline

    Total volume resulting from the sum of the volume of the pulmonary compartment of the costal, abdominal gradient of the costal and abdominal beds.

  5. Oxygen uptake

    Time frame: Baseline

    Consumption of oxygen during an effort.

  6. Diaphragm mobility

    Time frame: Baseline

    It is the diaphragmatic movement from the end of the expiration until the end of the inspiration, being able to be realized in tidal volume or starting from the total pulmonary capacity.

  7. Diaphragm thickness

    Time frame: Baseline

    Defined as a corpulence of the diaphragm muscle

Sponsors and collaborators

Lead sponsor

Universidade Federal de Pernambuco

Other

Registry information

Official study title

BODY COMPOSITION, PERIPHERAL MUSCULAR FORCE, KINEMATIC THORACIC-ABDOMINAL, VENTILATORY METABOLIC RESPONSE, DIAPHRAGM MOBILITY AND THICKNESS PREDICTION OF OBSTRUCTION LEVEL OF COPD?

Important dates

Study start
2016
Primary completion
2018
Study completion
2018
First posted
Mar 22, 2017
Registry last updated
Nov 7, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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