Evaluation of Respiratory Function and Functional Capacity in Pediatric Patients With Chronic Kidney Disease (CKD)

Chronic kidney disease (CKD) is defined as a permanent abnormality in kidney structure or function that persists for more than 3 months (for example, glomerular filtration rate [GFR] <60 mL/min/1.73 m2 or albuminuria ≥30 mg/24 hours) and, it effects the 8% to 16% of the population worldwide.In pediatric patients with CKD, exercise capacity begins to decline in stage 3 of the disease and progressively decreases in stage 5, in dialysis and transplant patients (4, 5). Reduction in respiratory muscle strength and six minute walk test (6MWT) is observed in patients with CKD treated with hemodialysis (HD).The aim in present study is to evaluate the relationship between functional capacity and respiratory functions in stage 1-5 pediatric chronic kidney disease patients.

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Key information

Conditions

Chronic Kidney Diseases Chronic Disease Chronic Renal Disease Chronic Renal Failure Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Kidney Failure, Chronic Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Renal Insufficiency, Chronic Urogenital Diseases Urologic Diseases

Age range

5 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Acibadem Mehmet Ali Aydınlar University

Istanbul, 34752, Turkey (Türkiye)

About this study

The aim of this study is to evaluate functional capacity with six minutes walk test (6MWT), respiratory functions with spirometer and the correlation between functional capacity and respiratory functions in pediatric CKD patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Being between the ages of 5-18, having stage I-V chronic kidney disease,
Having chronic kidney disease for at least 6 months,
Not having visual and hearing impairment

Exclusion criteria

Presence of mental retardation,

Insufficient Turkish communication, Inability to communicate,
Having metabolic-neurological problems,
Presence of cardiomyopathy, angina pectoris,
Presence of orthopedic problem that will prevent standing and walking
Cerebrovascular disease
Patients will not be included in the study in the presence of metastatic carcinoma.

Treatment and study plan

6 minute walk test,

Other

submaximal exercise test used to evaluate the functional capacity of patients

Other names: pulmonary function tests

Primary outcomes

6 minute walk test

Time frame: during the procedure

its a submaximal exercise test. The 6MWT is carried out in a marked 30 meter corridor. Patients are asked to walk as quickly as possible. They can stop whenever they want. The distance walked is recorded in meters. And it is interpreted according to the reference values of healthy children.quicly as possible and the distance will be record in meter.

Secondary outcomes

pulmonary function test

Time frame: during the procedure

FVC, FEV1, FEV1/FVC, PEF parameters will be eveluated.Patients sit with a clip on their noses. After 3 technically appropriate tests, the best measured values are recorded and compared against reference values.The measurements obtained are recorded as a percentage relative to their ratio to the expected reference values.FEV1, FVC,PEF measurements are recorded as a volume in ml.

Sponsors and collaborators

Lead sponsor

Acibadem University

Other

Registry information

Important dates

Study start: 2022
Primary completion: 2022
Study completion: 2022
First posted: Apr 21, 2022
Registry last updated: Jul 25, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed