Evaluation of Pupil Dilation Speed With the MAP Dispenser

After screening, eligible subjects will be scheduled for 2 treatment visits where either 1 mist or 2 mists of the study drug will be administered to both eyes according to a pre-specified randomization plan. Safety evaluations and efficacy measurements will be performed at specified time intervals thereafter.

Pupil dilation for each treatment will be compared at each time interval.

Inclusion criteria

• Photopic screening pupil diameter ≤ 3.5 mm in each eye

Exclusion criteria

• Allergy to phenylephrine hydrochloride, tropicamide, or benzalkonium chloride.
• Use of benzodiazepines, monoamine oxidase inhibitors, tricyclic antidepressants, anticonvulsants, cholinergic drug at screening or anticipated during the study period.
• History of closed-angle glaucoma.
• Anatomically narrow anterior chamber angles (Van Herrick grade ≤ 2 in either eye).
• Ocular surgery or laser treatment of any kind prior to the Screening Visit.
• History of iris trauma, surgery, or atrophy.
• Irregularly-shaped pupil secondary to ocular trauma or congenital defect, or history of neurogenic pupil disorder.