School of Rehabilitation
Shiraz, Fars, 33669-71947, Iran
NCT Number: NCT02487914
Drug delivery is conducted through various methods such as injection, phonophoresis, and iontophoresis. Iontophoresis is defined as the noninvasive delivery of active ions through epidermis using direct current. The direct current has some disadvantages such as skin burning and limited time of application. Interferential current is a kind of alternating currents without limitations of direct current; so the purpose of this study was to investigate and compare the effects of Lidocaine, interferential current and Lidocaine iontophoresis using interferential current.
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Notify Me18 year–25 year
Female
Interventional
Phase 2 / Phase 3
Shiraz, Fars, 33669-71947, Iran
Pressure, tactile, and pain thresholds were evaluated before and after the application of Lidocaine, interferential current and Lidocaine iontophoresis using interferential current. Pressure threshold was investigated with a Pesula. Pesula is a pen-like scaled mechanical device that measures the skin pressure threshold. Pesula was pressed to the skin and pressure threshold was measured in mm. Pain and tactile thresholds were investigated using an electrical stimulator.The intensity was gradually increased to the extent that the participant reported a tingling sensation. The displayed intensity was considered as the tactile sense threshold. Then, the intensity was increased to the extent to be intolerable for the participant and this intensity was considered as the maximum pain threshold. The thresholds were recorded in milliampere.
Lidocaine iontophoresis using interferential current can increase perception threshold of pain, and pressure sense more significantly in comparison to the application of Lidocaine and interferential current alone.
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
Exclusion criteria
drug delivery through interferential current.
Other names: Dynatron 438, Enraf Nonius Comp., Netherlands
Other names: Xylocaine 10% spray, AstraZeneca, Korea
Other names: Dynatron 438, Enraf Nonius Comp., Netherlands
Time frame: up to one week
pain threshold to increasing intensity of interferential current.
Time frame: up to one week
exact perception of the lowest level of interferential current
Time frame: up to one week
Pesula was used to evaluate tactile threshold.
Shiraz University of Medical Sciences
Other
Iontophoresis Effects on Senses
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