Evaluation of Potential Vitamin D Effects on Muscle: a Pilot Study

People who do not have adequate amounts of vitamin D develop weakness of leg and arm muscles. This study will determine if vitamin D supplementation benefits muscle functions important for swallowing, bladder and bowel function.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Dysphagia Deglutition Disorders Digestive System Diseases Esophageal Diseases Fecal Incontinence Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Gastrointestinal Diseases Intestinal Diseases Lower Urinary Tract Symptoms Male Urogenital Diseases Otorhinolaryngologic Diseases Pathological Conditions, Signs and Symptoms Pharyngeal Diseases Rectal Diseases Signs and Symptoms Urinary Incontinence Urination Disorders Urogenital Diseases Urologic Diseases Urological Manifestations

Age range

70 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

UW Osteoporosis Clinical Research Program

Madison, Wisconsin, 53705, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who present for evaluation to the UW Geriatric clinic including Dr. Pryzbelski's subspecialty, or Osteoporosis clinics
Age 70 years or older
Cognitively intact, as determined by the attending physicians at above mentioned clinics

Exclusion criteria

History of, on ongoing, renal failure
History of liver failure
Known malabsorption
Known disorders of parathyroid function, hyper/hypocalcemia, or other abnormalities of calcium or phosphate metabolism
Known history of vitamin D intoxication or granulomatous disease
active seizure disorder
Pain associated with temporomandibular joint (TMJ)

Treatment and study plan

Ergocalciferol (vitamin D2)

Other

50,000 IU 3 times weekly for 4 weeks

Primary outcomes

change in lingual strength and perceived swallow function

Time frame: 4 weeks

Secondary outcomes

change in perceived bowel and bladder function

Time frame: 4 weeks

Sponsors and collaborators

Lead sponsor

University of Wisconsin, Madison

Other

Registry information

Important dates

Study start: 2006
Primary completion: 2010
First posted: Jan 15, 2008
Registry last updated: Oct 5, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed