Evaluation of Persistence of Immunity in 4-year-old Children Previously Immunised With IPV-Al AJV (Picovax®)

Inclusion criteria

• Children that have been vaccinated with IPV-Al AJV in the VIPV-07 and VIPV-07 E1 trials and have completed these trials
• Healthy, as assessed from medical history and physical examination
• Parent(s)/guardian(s), according to the local legal requirements, have been properly informed about the trial and have signed the informed consent form
• Parent(s)/guardian(s), according to the local legal requirements, have been granted access to the child´s trial related medical records
• Parent(s)/guardian(s), according to the local legal requirements, are likely to comply with trial procedures

Exclusion criteria

• Previous vaccination with OPV
• Previous vaccination with IPV outside the VIPV-07 and VIPV-07 E1 trials
• Known or suspected immunodeficiency (e.g. leukaemia, lymphoma) or family history of congenital or hereditary immunodeficiency. HIV is not an exclusion criterion.
• Severe uncontrolled chronic (e.g. neurologic, pulmonary, gastrointestinal, hepatic, renal or endocrine) disease
• Known or suspected allergy to vaccine constituents (e.g. hypersensitivity to formaldehyde and/or 2-phenoxy-ethanol)
• Uncontrolled coagulopathy or blood disorder contraindicating intramuscular injections or blood sampling
• Treatment with a product which is likely to modify the immune response (e.g. blood products and immunoglobulins) prior to inclusion or planned during the trial period
• Participating in another interventional clinical trial
• Not suitable for inclusion in the opinion of the investigator