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Completed

NCT Number: NCT03442920

Evaluation of Periodontal Diseases and Obesity in Women

The aim of this study was to evaluate the effect of obesity and exercise on periodontal and biochemical parameters [serum, saliva and gingival crevicular fluid (GCF) adipokines (interleukin-1β, tumor necrosis factor-α, leptin, resistin and adiponectin)].

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Key information

Conditions

Periodontal Diseases Body Weight Mouth Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms Stomatognathic Diseases

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Kocaeli University

Kocaeli, 41190, Turkey (Türkiye)

About this study

It is thought that adipokines may play a role on periodontal disease in obese subjects, periodontal disease may also aggravate the existing systemic disease by changing the inflammatory parameters in the body. The aim of this study was to evaluate the effect of obesity and exercise on periodontal and biochemical parameters [serum, saliva and gingival crevicular fluid (GCF) adipokines (interleukin-1β, tumor necrosis factor-α, leptin, resistin and adiponectin)].

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Being women,
  • Older than 18 yrs old,
  • Not being pregnant,
  • Not being disabled,
  • For study group; being obese, not for healthy group being systemically health and in normal weight
  • Not treated periodontological in the last 6 months

Exclusion criteria

  • Younger than 18 yrs old,
  • Smokers who smokes more than 10 cigarettes in a day,
  • Uncontrolled systemic diseases,
  • Having periodontal treatment
  • who needs antibiotic prophylaxis

Treatment and study plan

Exercise

Other

This group made exercise for 12 week/3 times a week.

Primary outcomes

  1. Biochemical variables GCF

    Time frame: 12 week

    TNF-A, IL-1B,concentrations levels (pg/µl)

  2. Biochemical variables GCF

    Time frame: 12 week

    Leptin, adiponectin, resistin concentrations levels (ng/µl)

Secondary outcomes

  1. Biochemical variables_Saliva

    Time frame: 12 week

    TNF-A, IL-1B,concentrations levels (pg/µl)

  2. Biochemical variables_Saliva

    Time frame: 12 week

    leptin, adiponectin, resistin concentrations levels (ng/µl)

  3. Biochemical variables_Serum

    Time frame: 12 week

    TNF-A, IL-1B,concentrations levels (pg/µl)

  4. Biochemical variables_Serum

    Time frame: 12 week

    leptin, adiponectin, resistin concentrations levels (ng/µl)

Sponsors and collaborators

Lead sponsor

Kocaeli University

Other

Collaborators

  • The Scientific and Technological Research Council of Turkey

Registry information

Official study title

The Effects of Obesity and Periodontitis on Biochemical Parameters in Women Subjects

Important dates

Study start
2014
Primary completion
2015
Study completion
2016
First posted
Feb 22, 2018
Registry last updated
Feb 22, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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