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OpenTrials
Completed

NCT Number: NCT03667794

Evaluation of Novel Lung Function Parameters in Patients With Pulmonary Hypertension (PH)

Little is known about affection of small airways in patients with pulmonary hypertension as well as the ideal diagnostic approach. The investigators therefore aimed to evaluate novel or not widely used lung function tests for the evaluation of airway function in patients with PH.

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Key information

Conditions

Pulmonary Hypertension Cardiovascular Diseases Hypertension Hypertension, Pulmonary Lung Diseases Respiratory Tract Diseases Vascular Diseases

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • known or first diagnosis of PH

Exclusion criteria

  • inability to perform lung function testing
  • unable or unwilling to participate

Treatment and study plan

body plethysmography

Diagnostic Test

measurement of conventional lung function parameters

impulse oscillometry

Diagnostic Test

measurement of central and peripheral airway resistance

multiple breath washout

Diagnostic Test

measurement of ventilation heterogeneity

Primary outcomes

  1. LCI

    Time frame: 30 minutes

    between-group difference in lung clearance index (LCI)

  2. D5-20

    Time frame: 30 minutes

    between-group difference in frequency dependence of resistance (D5-20)

Secondary outcomes

  1. Discrimination small airway resistance

    Time frame: 30 minutes

    Evaluation of discriminative capability of impulse oscillometry

  2. Discrimination ventilation heterogeneity

    Time frame: 30 minutes

    Evaluation of discriminative capability of multiple breath washout

Sponsors and collaborators

Lead sponsor

Universitätsmedizin Mannheim

Other

Registry information

Important dates

Study start
2015
Primary completion
2017
Study completion
2017
First posted
Sep 12, 2018
Registry last updated
Sep 14, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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