Evaluation of Novel Lung Function Parameters in Patients With Bronchial Asthma

Current guideline-based criteria defining bronchial asthma do not always meet the challenges set by the complex pathophysiology of the disease. The investigators therefore aimed to evaluate novel or not widely used functional diagnostic approaches for the detection and therapeutic monitoring of patients with asthma.

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Key information

Conditions

Bronchial Asthma Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Pulmonary Healthy Controls Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

known or suspected bronchial asthma
known or suspected obstructive ventilation disorder
pulmonary healthy controls

Exclusion criteria

pregnancy
inability to participate

Treatment and study plan

impulse oscillometry

Diagnostic Test

impulse oscillometry

multiple breath washout test

Diagnostic Test

multiple breath washout test

body plethysmography

Diagnostic Test

body plethysmography

Primary outcomes

Global ventilation heterogeneity

Time frame: 30 minutes

lung clearance index (LCI) derived from sulphur hexafluoride multiple breath washout
Local ventilation heterogeneity

Time frame: 30 minutes

Sacin, Scond (Phase III slopes) derived from sulphur hexafluoride multiple breath washout

Sponsors and collaborators

Lead sponsor

Universitätsmedizin Mannheim

Other

Registry information

Important dates

Study start: 2015
Primary completion: 2018
Study completion: 2018
First posted: Jan 29, 2019
Registry last updated: Jan 29, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed