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Completed

NCT Number: NCT07378540

Evaluation of Microbial Status in Gastritis Patients in Different Periodontal Conditions

The aim of this study to evaluate the microbial profile in gastritis and healthy patients in different periodontal conditions via next generation technologies.

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Key information

Conditions

Periodontal Diseases Digestive System Diseases Dysbiosis Gastritis Gastroenteritis Gastrointestinal Diseases Mouth Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Stomach Diseases Stomatognathic Diseases

Age range

20 year–55 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Aydın Adnan Menderes University

Aydin, Turkey (Türkiye)

About this study

This study aims to determine the density of bacteria associated with periodontal disease and to evaluate oral dysbiosis in gastritis patients using metagenomic analysis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • no systemic diseases other than gastritis non-smoker

Exclusion criteria

  • Participants who took regular medications that could affect of periodontal tissue or oral microbiome pregnancy or lactation Patients who received periodontal treatment within the last 6 months

Treatment and study plan

Saliva Collection

Other

collecting unstimulated saliva

Primary outcomes

  1. Salivary microbial profile

    Time frame: 1 month

    To compare the oral flora profiles of the study groups, a microbiome-based next-generation sequencing approach targeting the 16S rRNA gene was employed. In this metagenomic study, following DNA extraction, phylogenetic classification was performed using the V3-V4 hypervariable regions of the 16S rRNA gene. Using the obtained data, total bacterial diversity and density were compared through alpha and beta diversity analyses. Bacterial taxa that differed between the groups were identified using LEfSe analysis.

Sponsors and collaborators

Lead sponsor

Aydin Adnan Menderes University

Other

Registry information

Official study title

Evaluation Of Periodontal Status In Gastritis Patients With Clinical And Microbiological Parameters

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Jan 30, 2026
Registry last updated
Jan 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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