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OpenTrials
Completed

NCT Number: NCT03276182

Evaluation of Meibomian Gland Dysfunction Before and After Cataract Surgery

This study will compare cataract patients before and after phacoemulsification. Evaluations will be performed before and 1 and 3 months following cataract surgery, including parameters of dry eye syndrome and MGD. Dry eye syndrome parameters included TBUT, Schirmer's test type I, Oxford staining score, and the Ocular Surface Disease Index (OSDI) Questionnaire. MGD parameters consisted of lipid layer thickness (LLT), lid margin abnormality, meibum quality, meibum expressibility, MG orifice obstruction, MGD stage, and MG dropout.

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Key information

Conditions

Cataract Patients

Age range

19 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Department of Ophthalmology, Yonsei University College of Medicine

Seoul, 03722, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with cataract surgery planning with phacoemulsification and intraocular lens implantation with or without mild dry eye syndrome

Exclusion criteria

  • the previous use of eye drops, except artificial tears within 3 months before cataract surgery
  • a history of previous ocular surgery or trauma
  • the presence of ocular comorbidities such as glaucoma, uveitis, cystoid macular edema, and any surgical complications including rupture of the posterior capsule during cataract surgery.

Treatment and study plan

Lipiview 2

Device

Tear film lipid layer thickness and meibomian gland dropout were measured by LipiView interferometer (TearScience Inc, Morrisville, NC)

Primary outcomes

  1. the change of parameters associated with dry eye syndrome

    Time frame: baseline and 1 month after POD(postoperative day)

    Analysis the change of parameters associated with dry eye syndrome before and after cataract surgery measured by lipiview 2.

  2. the change of parameters associated with meibomiangland dysfunction

    Time frame: baseline and 1 month after POD(postoperative day)

    Analysis the change of parameters associated with meibomiangland dysfunction before and after cataract surgery measured by lipiview 2.

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start
2015
Primary completion
2016
Study completion
2016
First posted
Sep 8, 2017
Registry last updated
Sep 8, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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