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Completed

NCT Number: NCT07651488

Evaluation of Intrathecal Hyperbaric Bupivacaine With Dexmedetomidine in Adults Undergoing Perianal Surgery

The aim of this study is to evaluate the effects of adding 5-mcg dexmedetomidine to hyperbaric bupivacaine in our population as it has never been published before, to enhance the duration of analgesia after perianal procedures requiring spinal saddle block and, thus reducing requirements of postoperative analgesics.

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Key information

Conditions

Duration of Analgesia Pain Score

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Liaquat National Hospital

Karachi, Pakistan

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing elective perianal surgery under spinal saddle block were included in the study.
  • Age between 40-80 years
  • ASA status I and II

Exclusion criteria

  • Pregnant women
  • Patient with coagulopathy
  • Infection at or near the needle insertion site
  • Allergy to the trial drug
  • Patient with chronic pain
  • Cognitive impairment
  • Patient with known drug or substance abuse

Treatment and study plan

Dexmedetomidine

Drug

dexmedetomidine 5 microgram added to 5 mg of 0.5% hyperbaric bupivacaine in dextrose injection

Hyperbaric bupivacaine % 0.5

Drug

5 mg of 0.5% hyperbaric bupivacaine in dextrose injection alone

Primary outcomes

  1. Duration of analgesia

    Time frame: 0 hour to 4 hours

    duration of analgesia was assessed from induction of anesthesia till patient discharge

Secondary outcomes

  1. Pain score

    Time frame: Two hours post surgery till 24 hours

    Pain will be assessed using Numeric Rating Scale (NRS) scale ranging from 0-10; 0 being no pain and 10 indicates the worst pain

Sponsors and collaborators

Lead sponsor

Liaquat National Hospital & Medical College

Other

Registry information

Acronym: DEX-BUP

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Jun 16, 2026
Registry last updated
Jun 16, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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