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Completed

NCT Number: NCT07184151

Evaluation of Guided Endodontic Microsurgery and Two Different Retrograde Filling Materials

The aim of this study was to evaluate the effect of guided endodontic microsurgical root end resection on bone healing compared to nonguided microsurgery using two different retrograde filling material (Well root putty, MTA) by cone-beam computed tomography.

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Key information

Conditions

Endodontic Re-treatment Failure

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry, Suez Canal University

Ismailia, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Tooth is restorable pocket depth is less than 4mm and mobility in its normal limit ( less than 1mm)
  • Persisting or emerging disease following root-canal treatment when root canal re-treatment is inappropriate.
  • Tooth with acceptable endodontic treatment and have a new post and crown restoration, but have a persistent or enlarging periapical lesion ( size less than 10 mm)
  • Obstructed canal (the obstruction proved not to be removable, by passed and the risk of damage was too great).
  • Extruded material or instrument with clinical or radiological findings of apical periodontitis and/or symptoms are present.

Exclusion criteria

  • Non restorable tooth
  • Contraindicating medical condition ( severe systemic condition and psychological condition)
  • Anatomical contra indication
  • Poor general oral status and supporting periodontal tissue.

Treatment and study plan

well root putty ( premixed bioceramic putty) retrograde filling

Drug

well root putty ( premixed bioceramic putty) retrograde filling

MTA retrograde filling

Drug

MTA retrograde filling

Primary outcomes

  1. Operating time

    Time frame: perioperative

    The operating time was measured from the beginning of osteotomy to the end of retrograde filling procedure

Secondary outcomes

  1. Change in bone density measurement over time

    Time frame: 1 week, 6 months

  2. Pain "Numerical Rating Scale (NRS)"

    Time frame: first day , 1 week

    Pain was categorized into four categorical scores: (1) none [score 0], (2) mild [score from 1-3], (3) moderate [score from 4-6], (4) severe [score from 7-10

  3. Change in Linear measurements over time

    Time frame: baseline and 6 months

    The evaluator located the slice on CBCT that will appear to demonstrate the largest size of the lesion and made a measurement of the lesion at what appeared to be the widest dimension. A second measurement of the widest dimension will be then made at 90 degrees to this initial measurement. These measurements will be made from a bone landmark to another bone landmark. These measurements will be performed in two planes for each lesion.

  4. Bone healing assessment

    Time frame: baseline and at 6 months

    For analysis of periapical radiographic healing, CBCT scans were oriented in the buccolingual plane along the longitudinal axis of the treated roots. The observers rated the radiographic healing based on the parameters described recently by von Arx et al. (2016) in. Healing was categorized and scored as follows: 1. Fully healed (score 2) , Partially healed (score 1) and Not healed (score 0)

  5. Change in volumetric measurement over time

    Time frame: 1 week, 6 months

Sponsors and collaborators

Lead sponsor

Suez Canal University

Other

Registry information

Official study title

Evaluation of Guided Endodontic Microsurgery and Two Different Retrograde Filling Materials:A Randomized Clinical Trial

Important dates

Study start
2022
Primary completion
2023
Study completion
2024
First posted
Sep 19, 2025
Registry last updated
Oct 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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