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NCT Number: NCT06249568

Evaluation of Fluid Responsiveness With Recruitment Maneuver After Sternotomy in Coronary Artery Bypass Surgery

Assuming that the basic reliability of dynamic indices will increase with the application of functional hemodynamic tests after sternotomy and protective lung ventilation in patients undergoing elective coronary artery bypass surgery, it is useful to predict fluid responsiveness after sternotomy in coronary artery bypass surgery patients ventilated with 6 ml/kg PBW (ideal body weight). We aimed to reveal the sensitivity and specificity of PPV and SVV changes by applying a lung opening maneuver.

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Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ankara Bilkent Şehir Hastanesi

Ankara, 06800, Turkey (Türkiye)

Location status: Recruiting

Location contact

ümit karadeniz

CONTACT

[email protected]

+905326025264

About this study

In order to evaluate the fluid deficit in patients undergoing coronary artery bypass surgery, researchers will measure stroke volume index, cardiac index and mean arterial pressure while the patients are in the lima position.

Then researchers will perform a lung opening maneuver (30mmHg for 30 seconds) and measure again.

researchers will measure again after the values return to normal. researchers will give patients balanced fluid at 3ml/kg and record their values.

Can researchers predict fluid response with lung opening maneuver?

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

  • Inclusion Criteria:
  • 1-ASA2-3 patients between the ages of 18-80 who will undergo elective coronary bypass surgery under general anesthesia
  • Exclusion Criteria:
  • 1. Be younger than 18 years old, be over 80 years old
  • 2. Patients with an ASA score greater than 3
  • 3. EF<40%
  • 4. Those with contraindications to anesthetic drugs
  • 5. Patients with BMI>30
  • 6. Patients who did not want to participate in the study
  • 7. Right ventricular dysfunction
  • 8. COPD(Chronic obstructive pulmonary disease)
  • 9. Bullous lung disease
  • 10. Moderate to severe PHT
  • 11. Severe kidney or liver disease
  • 12. Patients with hemodynamic instability in the perioperative period
  • 13. Pregnancy

Treatment and study plan

Primary outcomes

  1. Determination of fluid responsiveness in patients undergoing coronary arter bypass surgery.

    Time frame: from start to 4 months

    : Demonstration of fluid responsiveness in patients who will undergo coronary artery bypass surgery will prevent unnecessary fluid administration in case of hemodynamic disturbance, and medical treatments and interventions can be performed in a timely and targeted manner. Researchers will perform a recruitment maneuver on the patients and record mean arterial pressure and stroke volume index.

    Researchers will perform a recruitment maneuver on the patients and record mean arterial pressure and stroke volume index.

    Afterwards, researchers will give 3ml/cc balanced fluid to the patient and record the change in mean arterial pressure and stroke volume index.

Study contacts

Contact information is provided by the study sponsor or research team.

meltem sakman yılmaz

CONTACT

[email protected]

+90 505 922 1049

Sponsors and collaborators

Lead sponsor

Ankara City Hospital Bilkent

Other

Registry information

Acronym: fluidresponse

Important dates

Study start
2023
Primary completion
2024
Study completion
2024
First posted
Feb 8, 2024
Registry last updated
Jul 16, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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