Evaluation of Endoplasmic Reticulum Stress in Patients With Recurrent Pregnancy Loss

To evaluate endoplasmic reticulum stress in women with recurrent pregnancy loss and those who had healthy births in the same age group. The level of the unfolded protein X box binding protein 1 (XBP-1) is measured. It is aimed to show the effect of endoplasmic reticulum stress on recurrent pregnancy loss.

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Key information

Conditions

Recurrent Pregnancy Loss Endoplasmic Reticulum Stress

Age range

18 year–45 year

Sex eligibility

Female

Study type

Observational

Primary location

Pinar Yalcin Bahat

Istanbul, İ̇stanbul, 34000, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

with three or more miscarriages before 20 th week of gestation
had no chronic or acute inflammatory disease
used no steroids, anti-inflammatory, or antioxidant medications

Exclusion criteria

had inflammatory diseases
had systemic disease
Anatomical abnormalities, infectious, endocrine, or genetic etiologies

Treatment and study plan

x box binding protein

Other

Serum value (pg / mL) of x box binding protein (XBP-1), which is one of the unfolded proteins indicating endoplasmic reticulum stress, is measured.

Primary outcomes

Show the effect of endoplasmic reticulum stress on recurrent pregnancy loss

Time frame: 3 months

Serum value (pg / mL) of x box binding protein (XBP-1), which is one of the unfolded proteins indicating endoplasmic reticulum stress, is measured.

Sponsors and collaborators

Lead sponsor

Kanuni Sultan Suleyman Training and Research Hospital

Other

Registry information

Official study title

Endoplasmic Reticulum Stress in Recurrent Pregnancy Loss

Important dates

Study start: 2020
Primary completion: 2020
Study completion: 2020
First posted: Jul 2, 2020
Registry last updated: Jul 16, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed