Evaluation of Efficacy and Safety Parameters of Different Antibiotics Regimens for Management of Empyema

To evaluate the impact of using different antibiotic regimens including single and combined agents as the empirical therapy and evaluate the clinical outcomes regarding safety, efficacy, and pharmacodynamics parameters.

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Key information

Conditions

Empyema, Pleural Empyema Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Pleural Diseases Respiratory Tract Diseases Respiratory Tract Infections Suppuration

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Fayoum University hospital

Al Fayyum, Faiyum Governorate, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Confirmed Diagnosis of Empyema: Patients with a clinical and radiological diagnosis of

Exclusion criteria

1 - Hypersensitivity or Allergy to the selected antibiotic: Patients with a known history of hypersensitivity or allergic reactions to used antibiotics.

2- Pregnancy and Lactation

Treatment and study plan

Levofloxacin + clindamycin

Drug

Group 1

Levofloxacin + cefipime

Drug

Group 2

Primary outcomes

Evalutate different antibiotics

Time frame: 2 weeks

To evaluate the impact of using different antibiotic regimens including single and combined agents as the empirical therapy .

Sponsors and collaborators

Lead sponsor

Fayoum University

Other

Registry information

Important dates

Study start: 2024
Primary completion: 2026
Study completion: 2026
First posted: Jan 22, 2025
Registry last updated: Jun 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed