Skip to main content
OpenTrials
Completed

NCT Number: NCT00733564

Evaluation of Different Anesthesia for Uterine Curettage

Anesthesia during uterine curettage is a problem. Paracervical block is used in general for such an operation, though, the anesthetic efficacy is incomplete. Propofol is the short-lasting intravenous anesthetic administrated popularly. Sevoflurane is a new inhalational anesthetic well-known for it's "easy come, easy go" property. The investigators hypothesized that propofol, sevoflurane and paracervical block had different anesthetic efficacy during uterine curettage. Which one is the optimal selection for such operation needed to be evaluated.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Uterine Curettage Abortion, Induced

Age range

19 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Nanjing Maternal and Child Health Care Hospital

Nanjing, Jiangsu, 210004, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA status I-II
  • Performing abortion operation (medical- or surgical)
  • Requiring painless abortion

Exclusion criteria

  • < 19 yrs, and >=45 yrs
  • History of central active drugs administration
  • Drug abuse
  • Hypertension
  • Diabetes
  • Any other chronic diseases
  • Allergy to the study drugs
  • Habit of over-volume alcohol drinking
  • Records of history of centrally active drug use and psychiatry
  • Any organic disorder

Treatment and study plan

Lidocaine

Drug

Paracervical injection of 2% Lidocaine to block associated nociception input

Other names: Lignocaine

Propofol

Drug

Propofol 3mg/kg will be injected intravenously; 1 mg/kg will be added additionally for incomplete anesthesia

Other names: Diprivan

Sevoflurane

Drug

Sevoflurane 8% for anesthesia induction, 2-3% as the maintenance

Other names: Sevorane

Primary outcomes

  1. Bispectral Index (BIS) value

    Time frame: 0, 5, 10, 20, 30min after anesthesia

Secondary outcomes

  1. Intraoperative awareness

    Time frame: 0, 5, 10, 20, 30min after anesthesia

  2. Vital signs

    Time frame: 0, 5, 10, 15, 20, 25, 30min after anesthesia

  3. Arterial blood gas analysis

    Time frame: 5min before operation; 1min and 5min after beginning of the operation

  4. Pain intensity

    Time frame: 0, 5, 10, 20, 30min after surgical procedures

  5. Cortisol level

    Time frame: 30min before operation; 1 and 5min during operation

  6. Side effects

    Time frame: 30min after operation

  7. Uterine bleeding

    Time frame: 0min after completion of the operation; 1 hour after the operation

Sponsors and collaborators

Lead sponsor

Nanjing Medical University

Other

Registry information

Official study title

Evaluation of the Anesthetic Efficacy of Propofol,Sevoflurane and Paracervical Block for Uterine Curettage

Acronym: EDAUC

Important dates

Study start
2008
Primary completion
2009
Study completion
2009
First posted
Aug 13, 2008
Registry last updated
Mar 31, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.