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NCT Number: NCT07090746

Evaluation of Dentoalveolar Changes of Clear Aligners Versus Fixed Orthodontic Appliances on Skeletal Class I Non-extraction Patients With Dental Crowding

To evaluate dentoalveolar changes of clear aligners versus fixed orthodontic appliances on skeletal class I non-extraction patients with dental crowding.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Skeletal Class I Non-extraction Patients With Dental Crowding

Age range

18 year–22 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of dentistry mansoura university

Al Mansurah, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Complete permanent dentition.
  • Angle Class I malocclusion cases with mild to moderate crowding (2-6 mm) that can be resolved by dental expansion and interproximal reduction (IPR).
  • Good oral hygiene.

Exclusion criteria

  • Bad oral hygiene.
  • Previous orthodontic treatment.
  • Periodontal disease and previous periodontal surgery procedures.
  • Systemic diseases and/or craniofacial syndromes.

Treatment and study plan

Clear aligner

Device

Clear aligner

Fixed orthodontic appliance

Device

Fixed orthodontic appliance

Primary outcomes

  1. Alveolar bone thickness

    Time frame: From date of randomization until the date of first documented acceptable teeth alignment, assessed up to 12 months.

    Alveolar bone thickness will be assessed in vestibular and oral sides, parallel to the cervical reference line (CRL) at 3 different evels and expressed in millimeters.

  2. Alveolar bone height

    Time frame: From date of randomization until the date of first documented acceptable teeth alignment, assessed up to 12 months.

    Alveolar bone height loss will be measured perpendicularly to the CRL in both vestibular and oral sides. It will be represented as the difference between pretreatment and post treatment distance from alveolar crest to the CRL, expressed in millimeters.

Secondary outcomes

  1. Comparison of transverse dental changes between the two groups.

    Time frame: From date of randomization until the date of first documented acceptable teeth alignment, assessed up to 12 months.

    Assessment of inter-molar and inter-canine widths

  2. Assessment of Apical root resorption

    Time frame: From date of randomization until the date of first documented acceptable teeth alignment, assessed up to 12 months.

    comparison of root length changes after treatment

Sponsors and collaborators

Lead sponsor

Mansoura University

Other

Registry information

Official study title

Evaluation of Dentoalveolar Changes of Clear Aligners Versus Fixed Orthodontic Appliances on Skeletal Class I Non-extraction Patients With Dental Crowding: Randomized Controlled Clinical Trial

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Jul 29, 2025
Registry last updated
Jan 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.