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NCT Number: NCT07192133

Evaluation of CT-XPI

The goal of this clinical trial is to learn if a new computed tomography (CT) lung perfusion imaging method is as effective as standard of care (SOC) CT imaging. The main question it aims to answer is:

* Does the new contrast-free method provide more information about lung perfusion than SOC?

Participants will undergo a 30 minute chest CT.

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Key information

Conditions

CT Scan Computed Tomography

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

University of Wisconsin - Madison

Madison, Wisconsin, 53705, United States

Location status: Recruiting

Location contact

Matthew Smith, MD, PhD

PRINCIPAL_INVESTIGATOR

Timothy Szczykutowicz, PhD

SUB_INVESTIGATOR

About this study

The purpose of the study is to evaluate X-ray Pulsatility Index using prospectively acquired dynamic CT, which is different from conventional static CT scans.

The primary objective of this study is to collect dynamic CT scan data with human participants using high frame rate imaging methods to produce a map of lung perfusion.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 years or older
  • Able to sign and date the informed consent form
  • Will undergo a clinically-indicated CT exam of the head, neck, chest, abdomen, pelvis, or extremities

Exclusion criteria

  • Pregnant or lactating
  • In need of urgent or emergent care
  • Have any conditions that, in the opinion of the PI or designee, would interfere with the evaluation of the results or constitute a health hazard for the participant

Treatment and study plan

CT Scan

Diagnostic Test

Dynamic contrast-free chest CT scan

Primary outcomes

  1. Lung x-ray pulsatility index (XPI)

    Time frame: 30 minutes

    XPI, a representative of lung perfusion, will be measured using CT images. The dynamic x-ray attenuation from each pixel is analyzed using spectral analysis.

  2. Magnitude of XPI

    Time frame: 30 minutes

    Measured as a number, this corresponds to the magnitude of the relative change of signal.

  3. Presence of XPI

    Time frame: 30 minutes

    This will be evaluated quantitatively using CNR (contrast to noise) measurements which uses a region of interest in the lungs and a region of interest outside of the lungs.

  4. Spatial distribution of XPI signal

    Time frame: 30 minutes

    This is a subjective evaluation, routinely done clinically with other modalities that measure lung perfusion. Researchers evaluate how homogenous (smooth) the signal is over the lungs and look for perfusion defects (areas with little or no XPI) which would indicate pathology.

Study contacts

Contact information is provided by the study sponsor or research team.

Radiology Studies

CONTACT

[email protected]

608-282-8349

Sponsors and collaborators

Lead sponsor

University of Wisconsin, Madison

Other

Registry information

Official study title

Evaluation of Computed Tomography X-ray-Pulsatility Index (CT-XPI)

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Sep 25, 2025
Registry last updated
Jun 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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