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NCT Number: NCT05252676

Evaluation of Correlations Between Radiologic Features and Pathologic Subtypes of GGO LUAD Via WMS (ECTOP-1011)

This study is one of the Eastern Cooperative Thoracic Oncology Projects (ECTOP-1011). It aims to evaluate the correlations between radiologic features and pathologic subtypes of ground glass opacity featured lung adenocarcinoma via whole-mount section.

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Key information

Conditions

Adenocarcinoma of Lung Adenocarcinoma Carcinoma Lung Neoplasms Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fudan University Cancer Center

Shanghai, Shanghai Municipality, 200032, China

About this study

The pathological lepidic growth pattern was believed to relate to the ground-glass component, whereas invasive adenocarcinoma patterns relate to the solid component. However, the solid components might be fibrosis rather tumor; and previous studies demonstrated the ground-glass components might be invasive lesions. Therefore, it is of considerable significance to establish the correlations between radiologic features and pathologic subtypes of ground glass opacity featured lung adenocarcinoma.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Ground glass opacity featured lung nodule diagnosed by thin-section computed tomography(TSCT)
  • Pre-operation clinical IA stage
  • Pulmonary lobectomy or segmentectomy
  • Provision of informed consent

Exclusion criteria

  • Postoperative diagnosis of non-adenocarcinoma or mucinous adenocarcinoma
  • The surgical specimens fail to satisfy requirement of inflation and formalin fixation

Treatment and study plan

Primary outcomes

  1. Evaluation of correlations between radiologic features and pathologic subtypes

    Time frame: about 14 days

    Evaluation of correlations between radiologic features and pathologic subtypes of ground glass opacity featured lung adenocarcinoma

Secondary outcomes

  1. Specificity, Sensitivity, and Repeatability

    Time frame: about 14 days

    The specificity, sensitivity, and repeatability of invasiveness diagnosis based on the Whole-Mount Section

Sponsors and collaborators

Lead sponsor

Fudan University

Other

Registry information

Official study title

Evaluation of Correlations Between Radiologic Features and Pathologic Subtypes of Ground Glass Opacity Featured Lung Adenocarcinoma Via Whole-Mount Section

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Feb 23, 2022
Registry last updated
Jul 21, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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