Evaluation of Corrected Carotid Artery Flow Time as a Predictor of Fluid Responsiveness in Spontaneous Breathing Patients

It is still challenging to assess intravascular volume status in spontaneously breathing patients. Recently, the measurement of corrected flow time in carotid artery was introduced as quite useful, simple and noninvasive for the evaluation of circulating blood volume change. The aim of this study is to evaluate whether corrected carotid artery flow time as determined by ultrasonography can be a predictor of fluid responsiveness in spontaneously breathing patients before induction of general anesthesia.

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Key information

Conditions

Brain Tumor Brain Diseases Brain Neoplasms Central Nervous System Diseases Central Nervous System Neoplasms Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms

Age range

19 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine

Seoul, 03722, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

adult patients (19-80 years of age) who were scheduled to undergo elective neurosurgery for brain tumor

Exclusion criteria

BMI > 35 or < 15 kg/m2
the presence of carotid artery stenosis > 50%
systolic blood pressure > 160 mmHg
cardiac rhythm other than sinus
intracardiac shunt 6. valvular heart disease
a left ventricular ejection fraction of < 50%
right ventricular dysfunction 9
chronic obstructive pulmonary disease
pulmonary hypertension
chronic kidney disease (eGFR < 60 mL/min/1.73m2)
pregnancy

Treatment and study plan

ultrasonographic measurement of corrected flow time in carotid artery

Device

Corrected carotid artery flow time is measured using 10-5 MHz linear probe on a portable ultrasound machine. On the two-dimensional image, the optimal image of the long-axis view is obtained at the left common carotid artery. The sample volume is placed on the center of the lumen, 2 cm proximal to the bulb, and a pulsed wave Doppler examination was performed while the Doppler beams were adjusted to ensure < 60° of angle for the best signal. Then, cardiac cycle time and carotid flow time is measured. Carotid flow time is measured between the upstroke of the flow tracing and the dicrotic notch, and it is corrected for pulse rate by dividing flow time by the square root of the cardiac cycle time to calculate corrected carotid artery flow time (flow time/√cycle time).

Primary outcomes

ultrasonographic measurement of corrected flow time in carotid artery

Time frame: right before fluid loading

The ultrasonographic measurement of corrected flow time in carotid artery will be performed before fluid loading.
ultrasonographic measurement of corrected flow time in carotid artery

Time frame: 5 minutes after fluid loading

The ultrasonographic measurement of corrected flow time in carotid artery will be performed 5 minutes after fluid loading.

Sponsors and collaborators

Lead sponsor

Yonsei University

Other

Registry information

Important dates

Study start: 2016
Primary completion: 2017
Study completion: 2017
First posted: Jul 25, 2016
Registry last updated: Jul 17, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed