Evaluation of Copeptin Levels in Elective Cesarean Section With Different Anesthetic Technique

During the delivery process, the mother and the baby generate some endocrine responses to this emotional and physical stressful action. Arginin-Vasopressin prohormone (copeptin), which is more stable and measurable in blood, is used as an endogenous stress indicator. Copeptin levels have been shown to be significantly increased in vaginally delivery when compared to cesarean section (c / s). In a caesarean section; it is a known fact that when the general anesthetic method and the used anesthetic substances are taken into consideration, it gives a significant stress to the mother and the baby. Spinal anesthesia with no impaired fetal oxygenation and without orotracheal intubation and neuromuscular blockers may reduce fetal distress. However, there was no study investigating the effect of the anesthesia techniques in elective cesarean section on the fetal stress and the level of copeptin, in the literature review. Therefore investigators aimed to compare spinal and general anesthesia technique in elective cesarean section, to evaluate level of copeptin and their relation with fetal distress.Investigators hope that this study will guide the anesthesia method that can be chosen primarily in caesarean section.

Inclusion criteria

• 18-40 years of age
• ASA I-II
• 36-40 gestational weeks
• BMI ≤ 40
• Undergoing elective cesarean section

Exclusion criteria

• Coagulopathy
• Known central or peripheral nerve disease
• fetal anomalies
• birth weight less than 2000 grams and above 4500 grams,
• infants with a risk of meconium or amniotic fluid aspiration
• kidney failure, diabetes mellitus, hypertension, cardiac disease, antepartum hemorrhage, asthma bronchiole, Rh incompatibility, congenital malformations