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OpenTrials
Completed

NCT Number: NCT02272205

Evaluation of Conventional Antibiotic Prophylaxis During a Change of Hip or Knee Infected at a Time

Infection is a serious complications after undergoing total hip replacement. It occurs in about 1% of cases. The optimal treatment of these infections is discussed. The team validated by international publications change strategy of the infected prosthesis at a time.

Antibiotic prophylaxis has significantly reduced the infection intraoperative contamination in orthopedic surgery rates. It must be conventionally administered before the surgical incision. In response to infection, it is typically recommended to start this antibiotic after the completion of the deep bacteriological samples, so as not to negate the risk of these samples by the prior administration of antibiotics. This attitude, however, is not formally validated by the scientific literature. In contrast, two recent publications challenge this practice, and suggest the use of a conventional antibiotic prophylaxis even in septic interventions. Our multidisciplinary team opted for a few months for this new strategy. We wish to evaluate the influence of this new approach results in the treatment of infection in total hip or knee.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients operated in service between January 2012 and July 2013 for treatment of an infection of total hip or knee.

Exclusion criteria

  • patients operated in service before January 2012 and after July 2013 for treatment of an infection of total hip or knee.

Treatment and study plan

Retrospective analysis of records

Other

Primary outcomes

  1. concordance of pre-and intraoperative bacteriological documentation

    Time frame: preoperative; intraoperative

    concordance of pre-and intraoperative bacteriological documentation (division into 3 classes: complete, partial, no - Chi-square test

Secondary outcomes

  1. rates to relapse of the initial infection or a new infection

    Time frame: preoperative; intraoperative

    rates to relapse of the initial infection or a new infection (survival curves according to Kaplan-Meier with log-rank test)

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Official study title

Evaluation of the Effect of a Conventional Antibiotic Prophylaxis on the Positivity of Intraoperative Bacteriological Samples During a Change of Hip or Knee Infected at a Time

Important dates

Study start
2014
Primary completion
2017
Study completion
2017
First posted
Oct 22, 2014
Registry last updated
Sep 5, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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