NCT Number: NCT02272205
Evaluation of Conventional Antibiotic Prophylaxis During a Change of Hip or Knee Infected at a Time
Infection is a serious complications after undergoing total hip replacement. It occurs in about 1% of cases. The optimal treatment of these infections is discussed. The team validated by international publications change strategy of the infected prosthesis at a time.
Antibiotic prophylaxis has significantly reduced the infection intraoperative contamination in orthopedic surgery rates. It must be conventionally administered before the surgical incision. In response to infection, it is typically recommended to start this antibiotic after the completion of the deep bacteriological samples, so as not to negate the risk of these samples by the prior administration of antibiotics. This attitude, however, is not formally validated by the scientific literature. In contrast, two recent publications challenge this practice, and suggest the use of a conventional antibiotic prophylaxis even in septic interventions. Our multidisciplinary team opted for a few months for this new strategy. We wish to evaluate the influence of this new approach results in the treatment of infection in total hip or knee.
Looking for future studies?
Notify MeKey information
Conditions
Age range
18 year and older
Sex eligibility
All sexes
Study type
Observational
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- patients operated in service between January 2012 and July 2013 for treatment of an infection of total hip or knee.
Exclusion criteria
- patients operated in service before January 2012 and after July 2013 for treatment of an infection of total hip or knee.
Treatment and study plan
Primary outcomes
-
concordance of pre-and intraoperative bacteriological documentation
Time frame: preoperative; intraoperative
concordance of pre-and intraoperative bacteriological documentation (division into 3 classes: complete, partial, no - Chi-square test
Secondary outcomes
-
rates to relapse of the initial infection or a new infection
Time frame: preoperative; intraoperative
rates to relapse of the initial infection or a new infection (survival curves according to Kaplan-Meier with log-rank test)
Sponsors and collaborators
Lead sponsor
University Hospital, Strasbourg, France
Other
Registry information
Official study title
Evaluation of the Effect of a Conventional Antibiotic Prophylaxis on the Positivity of Intraoperative Bacteriological Samples During a Change of Hip or Knee Infected at a Time
Important dates
- Study start
- 2014
- Primary completion
- 2017
- Study completion
- 2017
- First posted
- Oct 22, 2014
- Registry last updated
- Sep 5, 2025
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Related clinical trials
Published trials that share one or more normalized conditions with this study.
Morphine COnsumption in Joint Replacement Patients, With and Without GaBapentin Treatment, a RandomIzed ControlLEd Study
NCT00889148
Neurologic Manifestations, Pain
Hamilton, Ontario, Canada
View Trial DetailsEvaluation of X-ray, Acetabular Guides and CT in THR
NCT03072706
Total Hip Replacement
Coventry, West Midlands, United Kingdom
View Trial DetailsPatient Scores and Functional Tests After Hip Surgery
NCT07048041
Patient-reported Outcomes, Total Hip Replacement
Ordu, Turkey (Türkiye)
View Trial DetailsEffect of Pericapsular Nerve Group Block on Postoperative Cognitive Function
NCT06736405
Cognition Disorders, Cognitive Dysfunction
Çankaya, Ankara, Turkey (Türkiye)
View Trial Details