Evaluation of Comprehensive Geriatric Assessment and Laboratory Biomarkers in Elderly Patients With Multiple Myeloma

PRIMARY OBJECTIVE:

I. To evaluate the association between a baseline comprehensive geriatric assessment (cGA) and chemotherapy toxicity in the first 4 months of treatment measured by treatment-related adverse events, patient-reported outcomes (PROs), and treatment discontinuation in older patients (>= 65 years) with multiple myeloma (MM).

SECONDARY OBJECTIVES:

I. To evaluate the association between a baseline cGA and baseline disease- and host- related laboratory characteristics and cytogenetic risk profile by fluorescence in situ hybridization among newly diagnosed older (>= 65 years) patients with MM.

II. To evaluate how the cGA changes over 4 months from the start of treatment and the association between those changes and treatment response in older patients (>= 65 years) with MM.

III. To evaluate the association between proposed frailty biomarkers at baseline and treatment toxicity in the first 4 months of treatment measured by treatment-related adverse events, PROs, and treatment discontinuation in older (>= 65 years) patients with MM.

OUTLINE: This is an observational study.

Patients complete surveys and undergo cGA, blood sample collection, and electronic health record (EHR) review on study.

Inclusion criteria

• Age >= 65 years
• Diagnosis of MM based on International Myeloma Working Group (IMWG) diagnostic criteria
• Newly diagnosed or have received 1 prior line of treatment
• Planned to start a new treatment for MM within 30 days
• Transplant eligible or ineligible
• Fluent in English (all assessment tools are in English)
• Able to provide written informed consent

Exclusion criteria

• Received > 1 prior line of treatment
• Patients included in an interventional therapeutic trial
• Not able to give informed consent
• Severe mental or cognitive disorder precluding geriatric assessment