Evaluation of Bone Mineral Density Indications and Outcomes in Female Adolescents: Implications for Early Detection of Osteopenia/Osteoporosis and Gynecologic Practice

This retrospective study evaluates bone mineral density (BMD) measurements obtained by dual-energy X-ray absorptiometry (DEXA) in adolescent girls aged 12 to 21 years at a tertiary care center. The study focuses on patients referred from the adolescent gynecology clinic as well as from other medical specialties.

Key objectives are:

Comparing the BMD indications and results requested from the gynecology department with the indications and BMD results requested from other departments. Thus, the BMD scores of patients with hypogonadism can be compared with other groups at risk for bone health.

To assess BMD Z-scores across specific gynecologic diagnoses, including premature ovarian insufficiency, functional hypothalamic amenorrhea (FHA), and hypogonadotropic hypogonadism.

To analyze the relationship between gynecologic clinical features-such as age at menarche and duration of amenorrhea-and BMD Z-scores.

By combining clinical, hormonal, and densitometric data, this study aims to identify risk factors for low bone density in adolescents, support earlier recognition of osteopenia/osteoporosis, and provide guidance for appropriate interventions in adolescent gynecology practice.

Completed

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Key information

Conditions

Bone Density Amenorrhea Bone Diseases Bone Diseases, Metabolic Menstruation Disturbances Metabolic Diseases Musculoskeletal Diseases Nutritional and Metabolic Diseases Osteopenia Osteoporosis Pathologic Processes Pathological Conditions, Signs and Symptoms Primary Amenorrhea

Age range

12 year–21 year

Sex eligibility

Female

Study type

Observational

Primary location

Bagcilar Training and Research Hospital

Istanbul, 34200, Turkey (Türkiye)

About this study

Adolescence is a critical period for bone mass acquisition, and disturbances during this stage may predispose to osteopenia or osteoporosis in later life. Various clinical conditions encountered in gynecology, endocrinology, and other specialties may require evaluation of bone mineral density (BMD). However, data on referral indications and bone health outcomes in adolescents remain scarce.

This retrospective study focuses on female adolescents aged 12-21 years who underwent dual-energy X-ray absorptiometry (DEXA) scans at a tertiary care center. The cohort includes patients referred from the adolescent gynecology clinic as well as those referred from other medical departments.

The study objectives are:

To compare referral indications for BMD testing between gynecology and other specialties.

To evaluate differences in BMD Z-scores across specific gynecologic diagnoses, including premature ovarian insufficiency (POI), functional hypothalamic amenorrhea (FHA), and hypogonadotropic hypogonadism.

To examine the relationship between clinical features (such as age at menarche and duration of amenorrhea) and BMD outcomes within the gynecology group.

The analysis will provide insight into how referral patterns, gynecologic and endocrine conditions, and clinical characteristics influence bone health in adolescent girls. By highlighting risk factors for low BMD, the study aims to support earlier recognition and management of bone health problems in this population.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Female adolescents aged 12-21 years
Underwent bone mineral density (BMD) measurement with DEXA at the study center between 2020 and 2025
Available clinical and biochemical records, including referral indication

Exclusion criteria

Incomplete or missing BMD scan data
Insufficient clinical information in medical records
Patients with underlying conditions unrelated to bone health that preclude accurate evaluation (e.g., major skeletal deformities interfering with DEXA interpretation)

Treatment and study plan

Primary outcomes

Bone Mineral Density (BMD) Z-scores in Adolescent Girls

Time frame: At the time of DEXA scan (retrospective chart review, 2020-2025

Comparison of BMD Z-scores between adolescents (12-21 years) referred from the adolescent gynecology clinic and those referred from other specialties.

Sponsors and collaborators

Lead sponsor

Bagcilar Training and Research Hospital

Other Gov

Registry information

Official study title

Retrospective Evaluation of Bone Mineral Density Measurements, Clinical Indications, and Risk Factors for Osteopenia/Osteoporosis in Female Adolescents Attending at a Tertiary Care Center

Acronym: TEEN-BMD

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Sep 10, 2025
Registry last updated: Sep 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed