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Completed

NCT Number: NCT04679259

Evaluation of Blood Biomarkers as an Indicator of Delayed Neurocognitive Recovery

Delayed neurocognitive recovery is defined as a cognitive decline arising after surgery. In the present study, the authors evaluate the level of D-Amino Acid Oxidase, D-serine and Serine racemase in blood as an indicator of delayed neurocognitive recovery after cardiac surgery.

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Key information

Conditions

Postoperative Cognitive Dysfunction Cognition Disorders Cognitive Dysfunction Mental Disorders Neurocognitive Disorders Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Cognitive Complications Postoperative Complications

Age range

55 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

SMG-SNU Boramae Medical Center

Seoul, Select State/Province, 07061, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients scheduled for elective cardiac surgery

Exclusion criteria

  • MMSE <24
  • History of psychological or neurological diseases
  • Illiteracy
  • Preoperative delirium
  • Vision and hearing impairment

Treatment and study plan

Blood sampling for assessment of the level of D-Amino Acid Oxidase, D-serine and Serine in blood

Diagnostic Test

Blood sampling is done before surgery and at 1, 2, and 7 day after surgery. The level of D-Amino Acid Oxidase, D-serine and Serine in blood are assessed.

Neurocognitive test

Diagnostic Test

Neurocognitive test is performed before surgery and at 7 day after surgery

Assessment of delirium

Diagnostic Test

Postoperative delirium is assessed daily during 7 days after surgery.

Primary outcomes

  1. Change of concentration of D-Amino Acid Oxidase in blood at 1, 2, and 7 day after surgery

    Time frame: Before surgery and at 1, 2, and 7 day after surgery

    Blood level of D-Amino Acid Oxidase is assessed.

Secondary outcomes

  1. Concentration of D-serine in blood

    Time frame: Before surgery and at 1, 2, and 7 day after surgery

    Blood level of D-serine is assessed.

  2. Concentration of Serine racemase in blood

    Time frame: Before surgery and at 1, 2, and 7 day after surgery

    Blood level of Serine is assessed.

  3. Occurrence of delayed neurocognitive recovery

    Time frame: Before surgery and at 7 day after surgery

    Neurocognitive assessment

Sponsors and collaborators

Lead sponsor

SMG-SNU Boramae Medical Center

Other

Registry information

Official study title

Evaluation of Blood Biomarkers as an Indicator of Delayed Neurocognitive Recovery After Cardiac Surgery

Important dates

Study start
2021
Primary completion
2025
Study completion
2025
First posted
Dec 22, 2020
Registry last updated
Jan 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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