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OpenTrials
Completed

NCT Number: NCT05376657

Evaluation of Antioxidant and Skin Beauty Effects of Cherry Collagen Drink

To assess cherry collagen drink on skin condition improvement

Completed

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Key information

Conditions

Skin Condition Skin Diseases Skin and Connective Tissue Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chia Nan University of Pharmacy & Science

Tainan, 71710, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adults aged above 20 years old

Exclusion criteria

  • Subject who is not willing to participate in this study.
  • Patients with diseases of the skin, liver, kidney.
  • Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder.
  • Female who is pregnant or nursing or planning to become pregnant during the course of the study.
  • Received facial laser therapy, chemical peeling or UV overexposure (> 3 hr/week) in the past 4 weeks.
  • Constant drug use
  • Students who are currently taking courses taught by the principal investigator of this trial.
  • Body weight < 50 kg.

Treatment and study plan

Cherry collagen drink

Dietary Supplement

consume 1 sachet per day

Other names: YOUNIQUE DAILY YOU liquid collagen shot

Placebo drink

Dietary Supplement

consume 1 sachet per day

Primary outcomes

  1. The change of skin wrinkles

    Time frame: Change from Baseline skin wrinkles at 8 weeks

    VISIA Complexion Analysis System was utilized to measure skin wrinkles. Units: arbitrary units

  2. The change of skin texture

    Time frame: Change from Baseline skin texture at 8 weeks

    VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units

  3. The change of skin collagen density

    Time frame: Change from Baseline skin collagen density at 8 weeks

    DermaLab® Series SkinLab Combo was utilized to measure skin pores. Units: arbitrary units

  4. The change of skin elasticity

    Time frame: Change from Baseline skin elasticity at 8 weeks

    Soft Plus was utilized to measure skin elasticity. Units: arbitrary units

Secondary outcomes

  1. The change of skin melanin index

    Time frame: Change from Baseline skin melanin index at 8 weeks

    Soft Plus was utilized to measure skin melanin index. Units: arbitrary units

  2. The change of skin L* value

    Time frame: Change from Baseline L* value at 8 weeks

    Chroma Meter MM500 was utilized to measure skin L* value. Units: arbitrary units, 0-100

  3. The change of skin moisture

    Time frame: Change from Baseline skin moisture at 8 weeks

    Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120

  4. The change of skin spots

    Time frame: Change from Baseline skin spots at 8 weeks

    VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units

  5. The change of skin UV spots

    Time frame: Change from Baseline skin UV spots at 8 weeks

    VISIA Complexion Analysis System was utilized to measure skin UV spots. Units: arbitrary units

  6. The change of skin brown spots

    Time frame: Change from Baseline skin brown spots at 8 weeks

    VISIA Complexion Analysis System was utilized to measure skin brown spots. Units: arbitrary units

  7. The change of SOD-RBC of blood

    Time frame: Change from Baseline SOD-RBC at 8 weeks

    Venous blood was sampled to measure SOD-RBC

  8. The change of t-GSH of blood

    Time frame: Change from Baseline t-GSH at 8 weeks

    Venous blood was sampled to measure t-GSH

  9. The change of GST-RBC of blood

    Time frame: Change from Baseline GST-RBC at 8 weeks

    Venous blood was sampled to measure GST-RBC

  10. The change of blood total antioxidant capacity (TAC)

    Time frame: Change from Baseline TAC at 8 weeks

    Venous blood was sampled to measure concentrations of TAC

  11. The change of desmosine of blood

    Time frame: Change from Baseline desmosine at 8 weeks

    Venous blood was sampled to measure concentrations of desmosine

  12. The change of TNF-alpha of blood

    Time frame: Change from Baseline TNF-alpha at 8 weeks

    Venous blood was sampled to measure concentrations of TNF-alpha

  13. The change of transepidermal water loss (TEWL)

    Time frame: Change from Baseline TEWL at 8 weeks

    Tewameter® TM300 was utilized to measure TEWL. Units: g/hm²

Other outcomes

  1. The change of liver function biomarkers (AST, ALT) of blood

    Time frame: Change from Baseline liver function biomarkers at 8 weeks

    Venous blood was sampled to measure liver function biomarkers

  2. The change of renal function biomarkers (creatinine, BUN) of blood

    Time frame: Change from Baseline renal function biomarkers at 8 weeks

    Venous blood was sampled to measure renal function biomarkers

  3. The change of self-assessment skin condition

    Time frame: Change from Baseline skin condition at 8 weeks

    A self-assessment questionnaire was collected to evaluate skin condition

Sponsors and collaborators

Lead sponsor

TCI Co., Ltd.

Industry

Registry information

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
May 17, 2022
Registry last updated
Sep 29, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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