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OpenTrials
Completed

NCT Number: NCT05841589

Evaluation of Antimicrobial Efficacy of Green Tea, Garlic With Lime, Pomegranate Extract and Chlorhexidine Mouth Rinses in a Group of Egyptian Children (In-Vivo Study)

the aim of the clinical trial is to evaluate the antimicrobial efficacy of the herbal mouth rinses against chlorhexidine mouth rinse.

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Key information

Age range

5 year–8 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ain Shmas University

Cairo, Egypt

About this study

The present study was carried out on 84 children. Children were recruited based on certain inclusion criteria after signing a written informed consent by their parents. They were divided into 4 groups. Group (I) the children rinsed with Chlorhexidine mouth rinse, the child rinsed for 1 minute and plaque samples were collected from the child before and after rinsing. Group (II) children rinsed with green tea extract, while group (III) children rinsed with garlic with lime extract and group (IV) the children rinsed with pomegranate extract mouth rinse with the same procedures. .child satisfaction was measured using 5-point pictorial likert scale which is graded from 1 to 5 (1.Excellent.2.Good.3 Average 4.Poor. 5. Very poor).

All the plaque samples were collected and put in sterile test tubes containing thioglycolate as a transport media. They transferred to the microbiology laboratory within half an hour after rinsing for detection of bacterial counts. These samples were incubated 48-96 hours at 37°C. Number of bacterial colonies were counted by hand-held digital colony counter.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

• Age 5-8 years.

  • No history of systemic disease.
  • Patients didn't received antibiotics for at least 3 months before and during the study

Exclusion criteria

• Children who can't expectorate completely or brush their teeth on their own.

  • Fixed or removable orthodontic appliances.
  • Children with intra oral abscess, oral lesions or gingival diseases.
  • Parental consent was not acquired

Treatment and study plan

Green tea extract mouth rinse

Procedure

herbal extracts mouth rinse that was prepared in the microbiology laboratory

Garlic with lime extract mouth rinse

Procedure

herbal extracts mouth rinse that was prepared in the microbiology laboratory

Pomegranate extract mouth rinse

Procedure

herbal extracts mouth rinse that was prepared in the microbiology laboratory

Chlorhexidine mouth rinse

Procedure

herbal extracts mouth rinse that was prepared in the microbiology laboratory

Primary outcomes

  1. patient satisfaction

    Time frame: Through study completion, an average of 1 month

    Child satisfaction was measured using a 5-point pictorial likert scale .This Facial image scale was suitable and easy way to evaluate patient satisfaction about taste, smell and willing to use the mouth rinse. Its format was graded from 1 to 5 while 1 is the most satisfied and 5 is the least satisfied

Secondary outcomes

  1. bacterial count

    Time frame: 1 day after rinsing

    counting of Colony forming units was done by hand- held digital colony counter

Sponsors and collaborators

Lead sponsor

omnia sayed

Other

Registry information

Important dates

Study start
2018
Primary completion
2021
Study completion
2021
First posted
May 3, 2023
Registry last updated
May 3, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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