Evaluation of Anatomy, Clinical and Neuropsychological Long-term Sequelae of Patients Treated With Radiation Therapy for Brain Tumor

Inclusion criteria

In the case group:

• A history of solid brain tumor or haematological histologically proven.
• Patients previously treated with radiotherapy in this brain tumor (greater than or equal to 36 Gy dose).
• Radiotherapy treatment on a tumor in place or operated.
• Decline at least 10 years from the end of radiotherapy.
• Treatment with isocentric conformal radiotherapy.
• No other radiation therapy for locally recurrent brain metastases or new brain tumor.
• Lack of known brain metastases or meningeal carcinomatosis.

For the control group:

• Patients previously treated for cancer and disease relapse free for 10 years.
• No brain radiotherapy treatment.
• Lack of treatment with anti-cancer chemotherapy.
• Women of childbearing potential must be under effective contraception.
• Pairing according to age, sex, arms director and socio-cultural level.

For two groups:

• Man or woman aged (e) of minimum 18 years.
• Topic fluent French and comprising well.
• Free and Informed Consent signed.
• The subject should be affiliated to an appropriate social security system
• No cons-indication to MRI.
• The subject must have at least one primary school level

Exclusion criteria

In the case group:

• Brain radiotherapy carried out by intensity modulation technique.
• Radiation dose less than 36 Gy on the brain.
• Subject with against-indication to MRI.

For the control group:

• Previous history of brain radiotherapy.
• Previous history of brain surgery.
• Central neurological disorders, such as seizures, uncontrolled.

For two groups:

• Current Topics in oral chemotherapy or intravenous.
• Subject pregnant.
• Subject is not fluent in French or including bad.
• Any geographical conditions, social or associated psychopathology that could compromise the patient's ability to participate in the study.
• Participation in a therapeutic trial for less than 30 days.
• A person not affiliated with a social security scheme.