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Completed

NCT Number: NCT00951197

Evaluation of Alteration by Magnetic Resonance Imaging (MRI) in Dementia Among Elderly Subjects

Capturing the earliest stages of Dementia especially Alzheimer's Disease (AD) is a great challenge. Until now the NINCDS-ADRDA and the DSM criteria for AD were largely used as diagnostic standards in research. However, the research on AD progresses and some biomarkers have been recently suggested to improve the diagnostic criteria of AD, such as cerebrospinal fluid markers, neuroimaging with Positon Emission Tomography (PET) or Magnetic Resonance Imaging (MRI).

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Key information

Conditions

Dementia Alzheimer Disease Brain Diseases Central Nervous System Diseases Cognition Disorders Cognitive Dysfunction Disease Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Tauopathies

Age range

65 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Groupe Hospitalier Pellegrin - C.H.U. de Bordeaux

Bordeaux, 33076, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • participate in the AMI cohort
  • be aged 65 and older
  • be retired from agricultural profession
  • live in rural area in Gironde

Exclusion criteria

  • contraindication of MRI
  • left-handed
  • severe dementia
  • Parkinson's disease
  • poor health incompatible with the transport to neuroimaging service
  • to be left handed

Treatment and study plan

Neuroimaging

Other

Three successive MRI acquisitions to measure FA, MTR and T2 parameters.

Primary outcomes

  1. FA (Fractional Anisotropy), MTR (magnetization transfer ratio) and T2 (Transverse relaxation time) measures in patients with dementia compared to controls, in left and right hippocampus, and posterior cingulum

    Time frame: day 0

Secondary outcomes

  1. FA, MTR and T2 measures in subjects with mild cognitive impairment no dementia

    Time frame: day 0

  2. Performances in the 7 neuropsychological tests available in the AMI cohort

    Time frame: day 0

  3. FA measures for the connexion Hippocampus-cingulum posterior

    Time frame: day 0

Sponsors and collaborators

Lead sponsor

University Hospital, Bordeaux

Other

Registry information

Official study title

Estimation of Microstructure Alteration by MRI in Dementia Among Elderly Subjects Retired From Agricultural Profession and Living in Rural Area in Gironde - Participants From the AMI Cohort.

Acronym: AMIMAGE

Important dates

Study start
2009
Primary completion
2011
Study completion
2011
First posted
Aug 4, 2009
Registry last updated
Apr 30, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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