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NCT Number: NCT07593664

Evaluation of a Virtual Reality-based Version of the Multiple Errands Test in Alcohol Use Disorder

The goal of this study is to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive functions in patients with alcohol use disorder (AUD).

More specifically, the project aims to:

1. evaluate if the performance in the virtual version of the test is related to the performance in the original test in patients with AUD. 2. establish whether the virtual version of the test is sensitive enough to detect patients with or without an executive function deficit.

All participants will perform the original version (in a real-life supermarket) and the virtual version of the test (in a virtual reality environment).

Performance in the two versions of the test will be compared. Participants will also complete a battery of neuropsychological tests and questionnaires.

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Key information

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CH Le Vinatier, Bron, France

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About this study

The project aims to validate the virtual version of the Multiple Errands Test (V-MET) as a tool for assessing executive function in patients with alcohol use disorder (AUD), in comparison to the original test (MET), by:

  • establishing the ecological validity of the V-MET: a high correlation between performance on the MET and performance on the V-MET (total number of errors) in patients with TUAL and executive dysfunction.
  • establishing the sensitivity of the V-MET (to executive dysfunction): significant difference between V-MET performance in patients with an AUD and executive dysfunction versus (a) patients without executive dysfunction and (b) "healthy" volunteers

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • written consent
  • Normal or corrected vision and hearing
  • Membership or entitlement to a social security plan
  • spoken and written French
  • third party liability insurance

for patients only :

  • at least 6 criteria for AUD based on the Diagnostic and statistical manual of mental disorders
  • At the end of withdrawal: treatment with a diazepam equivalent of ≤ 20 mg/day

Exclusion criteria

  • under tutorship/ judicial protection
  • Sensory or motor impairment (impeding the use of virtual reality and/or mobility)
  • Severe neurological disorder (such as dementia or Korsakoff's syndrome)
  • Photosensitive epilepsy (contraindication for the use of virtual reality)
  • Any other condition deemed incompatible with the study, at the investigator's discretion
  • Montreal Cognitive Assessment (MoCA) score < 10 (severe cognitive impairment)
  • Breastfeeding or pregnant women
  • Familiarity with the supermarket visited during the MET test

For controls only :

  • History of alcohol use disorder
  • score ≥ 8 on the Alcohol Use Disorders Identification Test
  • Score on the Frontal Assessment Battery < 16 (or < 15 if education is below secondary level)

Treatment and study plan

Multiple Errand Test (MET)

Behavioral

The test takes place in a real supermarket. Participants must complete a list of tasks (e.g., purchasing certain items, collecting some information) while adhering to rules (e.g., not visiting the same place twice, etc).

Virtual MET

Behavioral

The test takes place in a virtual supermarket, developed on the C2Neuro app by C2CARE®.

Participants must complete a similar list of tasks to the MET (e.g., purchasing certain items, collecting some information) and adhere to similar to rules (e.g., not visiting the same place twice, etc) .

Primary outcomes

  1. Total number of errors on the test

    Time frame: Baseline

    Total number of errors on the MET and the V-MET.

    Errors include:

    • Inefficiencies (a more effective action could have been made)
    • Rule breaks: a specific rule is broken
    • Interpretation failure (the task is misunderstood or misinterpreted)
    • Task failure: not carried out or not completely completed

Secondary outcomes

  1. Inefficiencies on the test

    Time frame: Baseline

    Inefficiencies on the MET/V-MET : a more effective action could have been made Can be infinite

  2. Rule breaks on the test

    Time frame: Baseline

    Rule breaks on the MET / V-MET : a specific rule is broken

  3. Interpretation failures on the test

    Time frame: Baseline

    Interpretation failures on the MET/V-MET : the task is misunderstood or misinterpreted

  4. Task failures on the test

    Time frame: Baseline

    Task failures on the MET / V-MET : task not carried out or not completely completed

Study contacts

Contact information is provided by the study sponsor or research team.

Louis-Ferdinand LESPINE, PhD

CONTACT

[email protected]

+33437915155

Méline Devaluez, PhD

CONTACT

[email protected]

+33437915514

Sponsors and collaborators

Lead sponsor

Hôpital le Vinatier

Other

Registry information

Official study title

Evaluation of a Virtual Reality-based Version of the Multiple Errands Test for the Assessment of Executive Functions in Alcohol Use Disorder

Acronym: EVIMETAL

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
May 18, 2026
Registry last updated
May 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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