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NCT Number: NCT06682520

Evaluation of a Health System Integrated Model for Postpartum Education and Support in Rural Populations

This study was designed to evaluate the implementation of the Nurse Education and Support Team (NEST) Program for postpartum women who reside in 5 rural counties in North Carolina. Overarching Hypothesis: Mothers and infants residing in rural communities, randomized to the NEST-Rural care model over the 3-year course of the project will: 1. Receive more coordinated care for addressing social, mental and physical health needs. 2. Experience fewer postpartum hospital readmissions and decreased utilization of emergency departments (ED) for healthcare. 3. Experience higher adherence to American College of Obstetricians and Gynecologists (ACOG) and American Academy of Pediatrics (AAP) guidelines for preventive care, including recently updated ongoing postpartum care, serial well-child visits and vaccinations compared to those assigned to usual care. This group will be compared to those assigned to usual care,

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Key information

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Atrium Health Wake Forest Baptist

Winston-Salem, North Carolina, 27157, United States

Location status: Recruiting

Location contact

Angie Almond, MEd

CONTACT

[email protected]

336-713-4524

About this study

This is a Randomized Control Trial (RCT) designed study evaluating the implementation of the Nurse Education and Support Team (NEST) Program for postpartum women who reside in 5 rural counties (Davie, Davidson, Yadkin, Wilkes and Stokes counties) in North Carolina. The study cohort will be for all mothers residing in these rural counties and delivering their infant(s) in the Atrium Health Wake Forest Baptist Birth Center. It is anticipated that 1,300 mother-infant dyads will be enrolled and randomized to either usual care [visit 4-6 weeks postpartum] (~650) or NEST-Rural care (~650).

The NEST model is unique in that it supports both maternal and infant health, with an emphasis on using strategies aligned with evidence-based guidelines for postpartum and infant healthcare. Another important feature of NEST is integration of service delivery in the healthcare system. This integration facilitates reaching mother-infant dyads and bi-directional communication with the mother's and infant's healthcare providers to enable appropriate, timely healthcare. For example, as part of NEST, mothers are discharged from the hospital with a remote blood pressure monitor. Blood pressures are transmitted to a service hub through an app that is downloaded onto her phone prior to hospital discharge. The hub alerts the healthcare team, which follows-up with her to determine appropriate care.

Randomization to NEST-Rural services will include 3-5 nurse encounters with mothers and their infants in the postpartum period, postpartum remote blood pressure monitoring, breastfeeding support, infant weight checks, linking mothers and infants to needed social, behavioral, and health-related resources, and integration of service delivery with healthcare providers. Services will initiate in the postpartum hospital unit, with a NEST Coordinator introducing the program and identifying and making referrals and/or providing resources for emergent needs (e.g. pack-n-play, diapers), and offering and scheduling a follow-up nurse visit (home or telehealth-based, depending on needs) 2-3 weeks postpartum. Up to two additional nurse and/or social worker home/virtual visits will be provided, depending on the family's needs. At six weeks postpartum, the NEST Coordinator will contact the family to inquire whether any referrals were made and assess for continuing gaps in support. Following nurse encounters, a note will be sent to the mother's and infant's healthcare providers. If acute concerns are identified, the nurse will contact the provider immediately for additional care.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women that deliver an infant(s) at The Birth Center at Atrium Health Wake Forest Baptist and currently reside in Davidson, Davie, Stokes, Wilkes or Yadkin County in North Carolina
  • Women that delivered an infant(s) at home, were transported to Atrium Health Wake Forest Baptist and received postpartum care at The Birth Center and currently reside in Davidson, Davie, Stokes, Wilkes or Yadkin County in North Carolina
  • Ages 18 years or older

Exclusion criteria

  • Women that delivered an infant(s) and did not receive postpartum care at The Birth Center at Atrium Health Wake Forest Baptist.
  • Women that currently reside outside of Davidson, Davie, Stokes, Wilkes or Yadkin County in North Carolina
  • Under 18 years of age

Treatment and study plan

Postpartum NEST-Rural Program (Hospital based service model)

Other

NEST-Rural services will include 3-5 nurse encounters and, if indicated, up to 3 social work encounters with mothers and their infants in the postpartum period, postpartum remote blood pressure monitoring, breastfeeding support, infant weight checks, linking mothers and infants to needed social, behavioral, and health-related resources, and integration of service delivery with healthcare providers.

Primary outcomes

  1. Median number of hospital readmissions - Maternal

    Time frame: Baseline through 30 days postpartum

    Number of hospital readmissions in the 4th trimester

  2. Median number of hospital readmissions - Maternal

    Time frame: Baseline through 90 days postpartum

    Number of hospital readmissions in the 4th trimester

  3. Median number of encounters for urgent or emergent care - Maternal

    Time frame: Baseline through 30 days postpartum

    Number of visits to Urgent Care or the Emergency Room in the 4th trimester

  4. Median number of encounters for urgent or emergent care - Maternal

    Time frame: Baseline through 90 days postpartum

    To determine number of visits to Urgent Care or the Emergency Room in the 4th trimester

  5. Proportion of women that attend recommended postpartum visits

    Time frame: Baseline through 90 days postpartum

    Percentage of women that attended recommended visits to their obstetrician after delivery.

  6. Median number of hospital readmissions - Infant

    Time frame: Baseline through 30 days postpartum

    Number of hospital readmissions after birth following hospital discharge.

  7. Median number of hospital readmissions - Infant

    Time frame: Baseline through 90 days postpartum

    Number of hospital readmissions after birth following hospital discharge.

  8. Median number of encounters for urgent or emergent care - Infant

    Time frame: Baseline through 30 days postpartum

    Number of visits to Urgent Care or the Emergency Room following hospital discharge.

  9. Median number of encounters for urgent or emergent care - Infant

    Time frame: Baseline through 90 days postpartum

    Number of visits to Urgent Care or the Emergency Room following hospital discharge.

  10. Proportion of infants receiving a visit with an ambulatory care provider

    Time frame: Baseline through 21 days postpartum

    Percentage of infants that attended recommended visits to their pediatric care provider within 21 days following hospital discharge

  11. Proportion of infants that received >/= 4 well-child care visits with an ambulatory care provider

    Time frame: Baseline through 274 days postpartum

    Percentage of infants that attended recommended visits to their pediatric care provider within the first 9 months following hospital discharge

Secondary outcomes

  1. Median number of days with >/= 1 remote blood pressure obtained - Maternal

    Time frame: Baseline through 21 days postpartum

    Number of days that patients checked and remotely reported their blood pressure readings following hospital discharge.

  2. Proportion of women with a diagnosis of hypertensive disorders of pregnancy with at least one blood pressure obtained

    Time frame: Baseline through 10 days postpartum

    Percentage of women diagnosed with hypertensive disorders that checked and remotely reported at least one blood pressure reading.

  3. Proportion of women with preeclampsia with severe features with at least one blood pressure obtained

    Time frame: Baseline through 3 days postpartum

    Percentage of women with preeclampsia with severe features checked and remotely reported at least one blood pressure reading.

  4. Proportion of women exceeding 3 days length of stay in hospital after delivery

    Time frame: Baseline through date of hospital discharge

    Percentage of women that remain hospitalized for more than 3 days following delivery.

  5. Median length of stay for hospital readmissions after delivery

    Time frame: Baseline through 90 days postpartum

    Number of days mothers are readmitted and remain hospitalized after delivery.

  6. Proportion of women that attend a follow-up encounter with their primary care physician

    Time frame: Baseline through 365 days postpartum

    Percentage of women that have a follow-up visit with their primary care physician within the first year after giving birth.

  7. Proportion of women who receive a nurse home visit

    Time frame: Baseline through 30 days postpartum

    Percentage of women who receive a nurse home visit within 30 days of discharge

  8. Proportion of women eligible for an in-person home visit that received the in-person nurse visit

    Time frame: Baseline through 30 days postpartum

    Percentage of women eligible for an in-person nurse home visit that received the in-person home visit.

  9. Proportion of women eligible for an in-person social work home visit that received the in-person social work visit

    Time frame: Baseline through 45 days postpartum

    Percentage of women eligible for an in-person social work home visit that received the in-person social work visit

  10. Median number of hospital readmissions - Maternal

    Time frame: Baseline through 365 days postpartum

    Number of hospital readmissions within the first 2 years following delivery

  11. Median number of hospital readmissions - Maternal

    Time frame: Baseline through 730 days postpartum

    Number of hospital readmissions within the first 2 years following delivery

  12. Proportion of women scheduled for a mood check provider visit who received a mood check provider visit

    Time frame: Baseline through 21 days postpartum

    Number of women scheduled for a mood check visit and attended their mood check visit within 21 days of discharge after delivery

  13. Proportion of infants that received recommended immunizations

    Time frame: Baseline through Day 274

    Percentage of infants that received 3 hepatitis B, 2-3 rotavirus (depending on which one is given), 3 diphtheria/tetanus/pertussis, 3 haemophilus influenzae type B, 3 pneumococcal conjugate vaccines, 3 inactivated polio, and 1 flu vaccine within the first 9 months after discharge

  14. Proportion of infants exclusively receiving breastmilk at nurse encounter

    Time frame: Baseline through Day 21

    Percentage of infants exclusively breastfeeding at the time of the nurse home visit within the first 3 weeks after discharge.

  15. Proportion of infants receiving any amount of breastmilk at nurse encounter

    Time frame: Baseline through Day 21

    Percentage of infants receiving any breastmilk at the time of the nurse home visit within the first 3 weeks after discharge

  16. Median number of hospital readmissions - Infant

    Time frame: Baseline through day 365

    Number of hospital readmissions within the first 2 years following discharge.

  17. Median number of hospital readmissions - Infant

    Time frame: Baseline through day 730

    Number of hospital readmissions within the first 2 years following discharge.

Study contacts

Contact information is provided by the study sponsor or research team.

David M. Stamilio, MD, MSCE

CONTACT

[email protected]

336-716-0271

Elizabeth T. Jensen, MPH PhD

CONTACT

[email protected]

336-713-3132

Sponsors and collaborators

Lead sponsor

Wake Forest University Health Sciences

Other

Collaborators

  • The Duke Endowment

Registry information

Official study title

Evaluation of a Health System Integrated Model for Postpartum Education and Support in Rural Populations - NEST-Rural

Acronym: NEST-Rural

Important dates

Study start
2024
Primary completion
2027
Study completion
2029
First posted
Nov 12, 2024
Registry last updated
Oct 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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