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OpenTrials
Completed

NCT Number: NCT05105984

Evaluation of a Free-breathing Cardiac Cine-MRI Sequence With Image Reconstructions by Deep-Learning in Ischemic Heart Disease

Today, MRI is the gold standard for the precise assessment of left ventricular volume and function, but presents the drawback of having a long acquisition time and of generating motion artifacts, in particular respiratory artifacts, requiring repeated sequences in apnea to cover the whole cardiac volume. These apneas are difficult to achieve in patients with ischemic heart disease and may lead to degradation of the images, an increase in the duration of the examination by repeated acquisitions and therefore to diagnostic inaccuracies.

Artificial intelligence, already used in practice in cardiac MRI for automatic segmentation of the heart chambers, improves radiological interpretation with rapid and precise measurements. Deep-learning, which is part of artificial intelligence, would allow the reconstruction of cine-MRI sequences in free breathing, in order to overcome the artifacts from respiratory motions, and the improvement of diagnostic performance while improving examination conditions for patients.

Patients coming for a cardiac MRI for the assessment of ischemic heart disease will be eligible to the protocol. If the patient agrees to participate, a free-breathing cardiac cine-MRI sequence with Deep Learning based image reconstruction will be added to the usual protocol.

No follow-up will be required in this study.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Amiens-Picardie

Amiens, France, 80000

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age > or = 18 years old
  • Ischemic heart disease
  • Ability of the subject to understand and express his consent
  • Affiliation to the social security scheme

Exclusion criteria

  • Major obesity (> 140kg) not allowing the patient to enter the tunnel of the machine whose diameter is less than 70cm
  • Under 18 years old
  • Pregnant woman
  • Known allergy to gadolinium chelates
  • Claustrophobia
  • Any contraindication to MRI
  • Arrhythmia
  • Difficulty in holding apneas of more than 10 seconds

Treatment and study plan

Primary outcomes

  1. difference of LVEF measurements between Deep Learning reconstruction and the classic cine-MRI sequence

    Time frame: 5 minutes

    difference of LVEF measurements between Deep Learning reconstruction and the classic cine-MRI sequence

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire, Amiens

Other

Registry information

Official study title

Evaluation of a Free-breathing Cardiac Cine-MRI Sequence With Image Reconstructions Developed by Deep-Learning Compared to the Classic Apnea Cine-MRI Sequence in the Assessment of Ischemic Heart Disease.

Acronym: CINEDL

Important dates

Study start
2022
Primary completion
2023
Study completion
2024
First posted
Nov 3, 2021
Registry last updated
Nov 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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