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Completed

NCT Number: NCT01311544

Evaluation of 4D Magnetic Resonance Angiography (K-t Blast) of Supraortic Vessels in Acute Ischemic Stroke Patients

The Magnetic Resonance angiography (MRA) of supraaortic vessels is essential for the etiologic of stroke. However, the techniques usually used provide only static evaluation (degree of stenosis, occlusion) but not dynamic. An ultra-fast 3D MRA originally developed for the cardiac imaging, k-t blast (Broad-use Linear Acquisition Speed-up Technique) could be used to review the supraaortic vessels. This MRA offers the following advantages: short acquisition time, wide spatial coverage (of the thoracic aorta to the distal encephalic arteries), 3D spatial resolution and high temporal resolution. These qualities are even more optimal with a high magnetic field (3T). The high temporal resolution is interesting because it provides to repeat a volume every eight seconds and thus to have a dynamic evaluation of vascular filling and to assess the vascular supply of the infarcted territory. This sequence is classified as a 4D MRA.

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Key information

Conditions

Stroke, Acute Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Stroke Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Rennes University Hospital

Rennes, Brittany Region, 35033, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Men and women over 18 years
  • Eligibility for intravenous thrombolytic treatment (National Institute of Neurological Disorders and Stroke criteria)
  • Permanent ischemic stroke confirm with encephalic MRI (Magnetic Resonance Imaging)
  • Patient able of accepting protocol information
  • Patient who received information about the protocol and had not expressed its opposition to participate

Exclusion criteria

  • Pacemaker
  • Surgical ferromagnetic clips
  • Cochlear implants
  • Intraocular metallic foreign body
  • Iron implants or objects likely to concentrate the Radio Frequency field
  • Claustrophobia
  • Known intolerance to contrast media (DOTAREM)
  • Pregnant women (Beta Human Chorionic gonadotrophin performed for biological assessment of thrombolysis)
  • Patient with severe kidney with Glomerular Filtration rate < 30 ml/min
  • Persons subject to major legal protection (safeguarding justice, guardianship, trusteeship), persons deprived of liberty

Treatment and study plan

Primary outcomes

  1. Images quality for each cervical and intracranial arteries

    Time frame: 6 months

Secondary outcomes

  1. Quantification of carotid stenosis with NASCET classification

    Time frame: 6 months

  2. Study of dynamic vascular consequences of carotid stenosis

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Rennes University Hospital

Other

Registry information

Important dates

Study start
2011
First posted
Mar 9, 2011
Registry last updated
May 16, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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