Skip to main content
OpenTrials
Completed

NCT Number: NCT06409000

Evaluation of 3D Surface Scanning for Virtual-CT Based Radiation Therapy Treatment Planning

This study evaluates if three dimensional (3D) surface images can be used instead of the standard computed tomography (CT) scans for treatment planning in electron radiation therapy. 3D scanning has previously been used by several groups to design patient-specific devices to be 3D printed, and as has shown excellent agreement with CT obtained surfaces. Using 3D surface imaging instead of x-ray based CT, benefits include: no ionizing radiation used to produce images, shorter time between patient consultation and treatment, and ability to produce and evaluate patient-specific devices for electron therapy earlier in the treatment planning process. This study may help researchers learn how 3D surface scanning may be used to produce a virtual CT image of patient surfaces, and accurately replace traditional planning CT for treatment planning of electron based radiation therapy.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Hematopoietic and Lymphatic System Neoplasm Malignant Solid Neoplasm

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic in Arizona

Scottsdale, Arizona, 85259, United States

About this study

PRIMARY OBJECTIVES:

I. Develop and benchmark the necessary software to convert a 3D scan to a virtual CT.

II. Compare the spatial accuracy of virtual CTs from 3D scans to the planning CT.

III. Compare radiation treatment plans based on the virtual CTs from aim 2 to treatment plans based on the actual planning CTs.

OUTLINE: This is an observational study.

Patients undergo 3D surface scans on study. Patient's medical records are also reviewed on study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults (18 years old or older)
  • Capable of consent
  • Receiving electron therapy and a planning CT scan
  • Consent to two 3D surface scans of treatment area

Exclusion criteria

  • Pediatric patients
  • Mentally incapable of study consent
  • Receiving electron radiation for a breast cancer boost
  • Receiving electrons for total skin electron therapy
  • Patients with epilepsy or other seizure disorders

Treatment and study plan

Electronic Health Record Review

Other

Medical records reviewed

Three-Dimensional Imaging

Procedure

Undergo 3D surface scans

Other names: 3-D Imaging, 3-Dimensional Imaging, 3D Imaging, Medical Imaging, Three Dimensional

Primary outcomes

  1. Dose distribution agreement between virtual and planning computed tomography (CT) datasets

    Time frame: Up to 2 months

    The various three dimensional (3D) scans and CTs of the phantoms will be qualitatively assessed for agreement and accuracy to determine best practice, but there will be no statistical significance tested for. Will be conducted entirely on inanimate, plastic, anthropomorphic models (phantoms).

  2. Geometric agreement between virtual and planning CT datasets

    Time frame: Up to 2 months

    Will test for distance to agreement differences between 3D scans taken at different time points (consultation, simulation, and treatment).

  3. Geometric agreement between 3D scans taken at different time points

    Time frame: Up to 2 months

    Various dose metrics will be extracted from each of the three types of dose distribution: the ground truth CT based dose distribution, the 3D scan based virtual CT dose distributions, and the flat water phantom based dose distributions. Paired statistical tests will be used for each metric to test for significant differences between the various methods used to calculate the dose distributions.

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

3D Surface Scanning for Virtual-CT Based Radiation Therapy Treatment Planning

Important dates

Study start
2021
Primary completion
2026
Study completion
2026
First posted
May 10, 2024
Registry last updated
Feb 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.