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Completed

NCT Number: NCT01541514

Evaluating the Patient-Ventilator Synchrony During Mechanical Ventilation in Patients With Acute Lung Injury

The overall purpose to the study is to prospectively study how often patients with and without acute lung injury (ALI) have patient-ventilator asynchrony demonstrated as stacked breaths. The investigators seek to describe the quantity of stacked breaths by continuously recording flow, volume, and pressure waveforms routinely displayed on the vent. The investigators also seek to describe how primary ICU teams manage asynchrony documenting interventions of sedation or vent manipulation and what modality is most successful.

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Key information

Conditions

Mechanically Ventilated ICU Patients

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Chicago Medical Center

Chicago, Illinois, 60637, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age > 18 years intubated and mechanically ventilated diagnosed with acute lung injury (ALI) or requiring mechanical ventilation for reasons other than ALI

Exclusion criteria

neurological deficits (acute or chronic) that prevent effective diaphragm activity.

  • Neuromuscular disease affecting the diaphragm
  • Neuromuscular blockade

Treatment and study plan

Primary outcomes

  1. double stacks

    Time frame: number per minute over 5 minutes

    ventilator waveform recording

Secondary outcomes

  1. level of sedation

    Time frame: baseline

    Richmond Agitation Sedation Score

  2. mode of ventilation

    Time frame: 30min

    ventilator adjustment

Sponsors and collaborators

Lead sponsor

University of Chicago

Other

Registry information

Important dates

Study start
2011
Primary completion
2012
Study completion
2013
First posted
Mar 1, 2012
Registry last updated
Dec 3, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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