Completed

NCT Number: NCT02280226

Evaluating the Influence of Apnea on Cardiac Function Using Cardiac Magnetic Resonance Imaging.

Former studies revealed a distinct pattern of changes in circulation during deliberate apnea. Blood pressure rises significantly often accompanied by bradycardia. Further studies confirmed a massive increase of total vascular resistance as it also happens in shock to maintain perfusion of heart, lung and brain. This study is to determine the exact alterations of the cardiac function during this reaction, show the redistribution of blood volume in apnea and evaluate possible longterm effects on the central nervous system caused by repeated apnea via magnetic resonance imaging.

Completed

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Key information

Conditions

Physiological Changes in Deliberate Apnea

Age range

16 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Being able to hold breath deliberately at least 4,5 minutes

Exclusion criteria

Treatment and study plan

Magnetic Resonance Imaging (MRI)

Device

Primary outcomes

Cardiac Function: Duration of Apnea

Time frame: every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements

Alteration of cardiac function in subjects undergoing maximum apnea.
Mean Blood Flow Measurement Under Apnea Using MRI

Time frame: Every minute under apnea (from 0 up to 9 minutes and rest) depending on personal best with a mean of 5 measurements

Blood flow pattern in subjects undergoing maximum apnea.

Sponsors and collaborators

Lead sponsor

University Hospital, Bonn

Other

Registry information

Official study title

Evaluating the Influence of Apnea on Heart Function With Strain Analysis and Measurement of Fibrosis Derived From T1-mapping Using Cardiac Magnetic Resonance Imaging (MRI).

Important dates

Study start: 2014
Primary completion: 2016
Study completion: 2016
First posted: Oct 31, 2014
Registry last updated: Feb 7, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.