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NCT Number: NCT07146568

Evaluating the Implementation and Effectiveness of the Pink and Pearl Campaign on Lung Cancer Screening at Christian Hospital

Inspired by the ongoing Pink & Pearl Campaign, the breast radiology service of Christian Hospital in north St. Louis County will partner with Siteman Cancer Center to pilot this campaign in its mammography clinics in order to promote awareness, referral, and completion of lung cancer screening (LCS) among eligible women. This campaign leverages established infrastructure such as nurse navigation and referral to screening or primary care for further shared decision-making on cancer screening. The purpose of this study is to evaluate the effectiveness of the Pink & Pearl Campaign in improving LCS uptake among LCS-eligible women undergoing mammography at Christian Hospital. This evaluation is grounded in the Integrated Screening Action Model that depicts individual- and environmental-level influences on the screening behavior process. Using an explanatory sequential mixed methods design, which combines both quantitative and qualitative approaches, our specific aims for this proposal are to: a) assess whether the Pink & Pearl Campaign increases referrals and uptake/completion of LCS among LCS-eligible women undergoing screening mammography; b) determine median time-to-screening after referral to LCS; and c) evaluate individual and health system factors influencing LCS uptake and implementation outcomes of the campaign. These implementation outcomes will help identify whether the campaign was put in place successfully or not. This proposal will inform strategies for integrating cancer screening programs to improve poorly performing programs like LCS.

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Key information

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Barnes-Jewish Christian Hospital

St Louis, Missouri, 63136, United States

Location status: Recruiting

Location contact

Beryne Odeny, M.D. MPH, Ph.D.

CONTACT

[email protected]

314-362-1183

Beryne Odeny, M.D., MPH, Ph.D.

PRINCIPAL_INVESTIGATOR

Michelle V Lee, M.D.

CONTACT

[email protected]

314-454-7405

Michelle V Lee, M.D.

PRINCIPAL_INVESTIGATOR

Tabassum Ahmad, M.D.

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Eligibility Criteria - Interventional Study

  • Undergoing screening mammography at Christian Hospital
  • Between the ages of 50-80 years (inclusive)

Eligibility Criteria - Survey and Interview Sub-Studies

  • Part of the interventional study
  • Reporting a 20 pack-year equivalent of either current smoking history or have quit in the past 15 years
  • Can speak and understand English
  • Not diagnosed with a serious health problem that will limit life expectancy (such as previous history of lung cancer, symptoms of lung cancer such as hemoptysis or unexplained weight loss of more than 6.8 kg (15 lb) in the previous year)
  • Willing and able to get treatment if lung cancer is found
  • Able to understand and willing to sign an IRB-approved written informed consent document

Eligibility Criteria - Providers

  • At least 20 years of age
  • Involved in the breast radiology service or referred at least one patient to the Pink & Pearl Campaign
  • Able to provide verbal consent to participate in the interview

Treatment and study plan

Pink and Pearl Campaign

Other

This campaign leverages established infrastructure such as nurse navigation and referral to screening or primary care for further shared decision-making on cancer screening.

Primary outcomes

  1. Proportion of women referred from the breast radiology service who successfully complete LCS 6-months post-Pink & Pearl implementation

    Time frame: At 6 months

    The investigators will compare the baseline prevalence of LCS among women undergoing BCS to the prevalence of LCS among women undergoing BCS 6 months after implementation of the Pink & Pearl Campaign.

Secondary outcomes

  1. Median time-to-screening

    Time frame: At 6 months

    The investigators will compare differences in time-to-lung cancer screening across heterogenous populations

  2. Acceptability of Pink & Pearl Campaign

    Time frame: At 6 months

    Defined as the perception that the campaign is agreeable or satisfactory

Other outcomes

  1. Number of individual level barriers to LCS completion

    Time frame: At 6 months

  2. Number of health system level barriers to LCS completion

    Time frame: At 6 months

  3. Feasibility of Pink & Pearl Campaign

    Time frame: At 6 months

    Defined as extent to which strategy is suitable for a routine use in a setting

  4. Appropriateness of Pink & Pearl Campaign

    Time frame: At 6 months

    Defined as perceived fit, relevance or compatibility of the strategy or practice for a given setting

Study contacts

Contact information is provided by the study sponsor or research team.

Beryne Odeny, M.D., MPH, Ph.D.

CONTACT

[email protected]

314-362-1183

Michelle V Lee, M.D.

CONTACT

[email protected]

314-454-7405

Sponsors and collaborators

Lead sponsor

Washington University School of Medicine

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Aug 28, 2025
Registry last updated
Feb 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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