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OpenTrials
Completed

NCT Number: NCT01114581

Evaluating the Effect of Mucinex 1200mg on Mucociliary and Cough Clearance During an Acute Respiratory Infection

The purpose of this research study is to explore the mechanism of action of Mucinex, an oral, over-the-counter, FDA approved expectorant in patients with acute respiratory tract infections.

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Key information

Conditions

Acute Respiratory Infection

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Center for Environmental Medicine, Asthma, and Lung Biology

Chapel Hill, North Carolina, 27599, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Symptoms of cough, thickened mucus and chest congestion
  • Able to produce sputum
  • Non Smoker

Exclusion criteria

  • Pregnant
  • Smokers
  • Fever above 101°F
  • Any chronic illness

Treatment and study plan

Mucinex

Drug

Mucinex 1200mg (Guaifenesin) given as 2,600mg tablets, one time on day 1 of the study

Placebo

Drug

Placebo given as 2 tablets

Primary outcomes

  1. Percent of Inhaled Radioactive Tracer Particles Cleared From Lungs

    Time frame: 3 hours following inhalation of radioactive tracer particles

    Percentage of inhaled radioactive tracer (Ave180Clear)

Secondary outcomes

  1. Guaifenesin AUC(0-3)

    Time frame: 3 hours following dose administration

  2. Assess Sputum Properties (Objective Measures) and Symptoms (Subjective Measures) After Treatment With Mucinex or Placebo.

    Time frame: Within 10 days of developing symptoms associated with a respiratory tract infection

Sponsors and collaborators

Lead sponsor

Reckitt Benckiser LLC

Industry

Registry information

Acronym: MCC/CC

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
May 3, 2010
Registry last updated
Sep 19, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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