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Completed

NCT Number: NCT04624386

Evaluating Oxidative Stress in Menopause

Thiol disulfide levels will be determined using venous blood samples from pre- and postmenopausal women to evaluate oxidative stress in menopause. Furthermore, oxidative stress will be assessed according to age, and years since the start of menopause. Also, whether the presence of menopause related osteoporosis has any association with oxidative stress will be determined.

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Key information

Conditions

Menopause Oxidative Stress

Age range

30 year–75 year

Sex eligibility

Female

Study type

Observational

Primary location

Sisli Hamidiye Etfal Training and Research Hospital

Istanbul, 34371, Turkey (Türkiye)

About this study

A total of 77 subjects are divided into two groups: study group (postmenopausal women) and control group premenopausal women). Biometric data such as age, bmi, obstetric anamnesis, history of komorbidities, PAP smear results are recorded. Mammography results, dexa scores of post menopausal women are also obtained. Venous blood samples from all subjects are collected. Thiol disulfide levels will be determined from serum samples. Thiol disulfide levels will first be compared between the study and the control group in order to determine the oxidative stress in menopause. In secondary evaluation years of menopause, age, and dexa scores will be included.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Women who entered menopause as a natural process Women within the age limits Still menstruating healthy women as control subjects

Exclusion criteria

Women who have entered menopause prematurely Women who have entered menopause following a surgery Women with medically induced menopause Women without any autoimmune or chronic inflammatory diseases Women who are taking hormone replacement therapy due to menopausal symptoms Women without any malignant diseases

Treatment and study plan

Thiol disulfide level

Other

Venous blood is collected from all subjects and thiol disulfide levels will be determined from the serum samples obtained from the venous blood.

Primary outcomes

  1. Evaluating Oxidative Stress in Menopause

    Time frame: 2 months

    Thiol disulfide stress will be evaluated using serum samples from postmenopausal women and comparing these results with samples obtained from premenopausal women.

Secondary outcomes

  1. Evaluating Oxidative Stress According to Years of Menopause

    Time frame: 2 months

    Thiol disulfide levels will be determined and analysis will be done according to the years of menopause

  2. Evaluating Oxidative Stress According to Menopause Related Osteoporosis

    Time frame: 2 months

    Thiol disulfide levels will be determined and analysis will be done according to the osteoporosis scores evaluated with dxa

Sponsors and collaborators

Lead sponsor

Sisli Hamidiye Etfal Training and Research Hospital

Other

Registry information

Official study title

Evaluating Oxidative Stress in Postmenopausal Women

Important dates

Study start
2020
Primary completion
2020
Study completion
2020
First posted
Nov 10, 2020
Registry last updated
Dec 2, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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