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NCT Number: NCT07690657

Evaluating Intervention Allocation Policies for Reducing Hospital Readmissions at Michigan Medicine

The researchers are investigating if using a risk-based prediction score or benefit-based prediction score to allocate transition of care (TOC) interventions is more effective in reducing the rate of unplanned hospital readmissions or death within 30 days of hospital discharge.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

The University of Michigan

Ann Arbor, Michigan, 48109, United States

Location contact

Jenna Wiens, PhD

PRINCIPAL_INVESTIGATOR

Stephanie Shepard, PhD

CONTACT

[email protected]

734-647-1098

About this study

The intervention affects only how the TOC bundle is assigned and does not alter how the telephone calls are delivered. For example, both care navigators and pharmacists receive the same patient information and follow the same call procedures before and after the intervention.

Individuals with predicted benefits greater than the 40% quantile are assigned the phone call bundle while others were not assigned the bundle. During the trial the 40% quantile will be dynamically determined using discharge data from the previous week.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient meets the primary care established rule at Michigan Medicine (MM), AND
  • Patient's primary care physician (PCP) Department is one of our General Medicine or Family Medicine or Medical-Pediatrics departments, AND
  • Inpatient class is Inpatient or Observation or Obs Greater than 48 hours or Outpatient in a Bed or Extended Recovery or Hospital Care at Home Inpatient or Hospital Care at Home Observation, AND
  • Discharged from General Medicine or Family Medicine or Medicine Observation services, AND
  • Disposition of home or home with home care

Exclusion criteria

  • Physician Organization of Michigan Accountable Care Organization (POM ACO)
  • Sepsis patients (had a diagnosis of sepsis during admission, active or resolved on the hospital problem list)

Treatment and study plan

C-HARP TOC assignment

Device

The Experimental Arm will allocate TOC interventions based on scores generated by the Causal-Hospital reAdmission Risk Prediction Model (C-HARP), C-HARP is a linear model that leverages routinely collected and stored patient data in the electronic health record (EHR) to estimate how much a patient will benefit from receiving Michigan Medicine's (MM's) TOC telephone call bundle.

The LACE Index TOC assignment

Other

The LACE Index has four components: Length of Stay (L), Acuity of the Admission (A), Comorbidities (C), and Emergency Department Visits (E), and estimates the risk of a patient having an unplanned hospital readmission after being discharged from their current encounter.

Primary outcomes

  1. The number of 30-day all-cause unplanned readmission or death

    Time frame: 30 calendar days following the index discharge

    An unplanned readmission is defined as any not canceled inpatient, outpatient, or observation hospital admission with an admission type not recorded as "scheduled." Deaths are determined using the Michigan Death Index and matched to patient records using Social Security numbers.

Secondary outcomes

  1. The number of 90-day all-cause unplanned readmission or death

    Time frame: 90 calendar days following the index discharge

    An unplanned readmission is defined as any not canceled inpatient, outpatient, or observation hospital admission with an admission type not recorded as "scheduled." Deaths are determined using the Michigan Death Index and matched to patient records using Social Security numbers.

  2. Time to first 90-day all-cause unplanned readmission or death

    Time frame: 90 calendar days following the index discharge

    An unplanned readmission is defined as any not canceled inpatient, outpatient, or observation hospital admission with an admission type not recorded as "scheduled." Deaths are determined using the Michigan Death Index and matched to patient records using Social Security numbers.

  3. TOC telephone call bundle completion (care navigator call)

    Time frame: 5 calendar days after discharge.

    A care navigator call is considered complete if a completed call record is observed within 5 calendar days after discharge.

    Calls are considered incomplete if the corresponding completed call record occurs after an all-cause unplanned readmission.

  4. TOC telephone call bundle completion (clinical pharmacist call)

    Time frame: 14 calendar days after discharge

    A clinical pharmacist call is considered complete if a completed call record is observed within 14 calendar days after discharge.

    Calls are considered incomplete if the corresponding completed call record occurs after an all-cause unplanned readmission.

  5. TOC telephone call bundle completion (both calls)

    Time frame: 14 calendar days after discharge

    Completed the care navigator call and completed the clinical pharmacist call.

    Calls are considered incomplete if the corresponding completed call record occurs after an all-cause unplanned readmission.

Study contacts

Contact information is provided by the study sponsor or research team.

Stephanie Shepard, PhD

CONTACT

[email protected]

734-647-1098

Sponsors and collaborators

Lead sponsor

University of Michigan

Other

Registry information

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jul 8, 2026
Registry last updated
Jul 8, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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