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NCT Number: NCT06921447

Evaluating Decision-making Using ChatGPT-4 Among Trainees in Surgery

This study aims to assess whether ChatGPT-4 can support surgical trainees in clinical decision-making. By comparing the performance of ChatGPT-4 with junior residents, senior residents, and attending surgeons on standardized clinical scenarios, the study seeks to understand the potential role of large language models in surgical education. The ultimate goal is to evaluate whether ChatGPT-4 can be safely integrated as a supplementary educational tool to aid junior residents in developing critical thinking and surgical judgment.

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Key information

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Trieste

Trieste, Italy

Location contact

Manuela Mastronardi

CONTACT

[email protected]

0403994152

Manuela Mastronardi

PRINCIPAL_INVESTIGATOR

Margherita Sandano

SUB_INVESTIGATOR

Paola Germani

SUB_INVESTIGATOR

Silvia Palmisano

PRINCIPAL_INVESTIGATOR

About this study

Background:

Artificial Intelligence (AI) is rapidly transforming the medical landscape, offering new possibilities in education, diagnostics, and decision support. In surgery, clinical decision-making is a core competency developed progressively through training. ChatGPT-4, a state-of-the-art large language model developed by OpenAI, has demonstrated competence in handling medical queries and clinical reasoning tasks. However, its performance in complex surgical decision-making compared to human trainees remains largely unexplored.

Objective:

The EDuCATe study aims to evaluate the accuracy and reliability of ChatGPT-4's responses to clinical scenarios involving general surgery cases. Specifically, the study compares the model's performance to that of junior residents, senior residents, and attending surgeons to understand if ChatGPT-4 can serve as a safe and effective educational tool for surgical trainees.

Methods:

Seven clinical scenarios will be constructed using real anonymized patient data representing common general surgery conditions. Each case will be presented step-by-step, mimicking the clinical decision-making process. Participants will answer a question related to treatment choice.

Participants will include junior residents (PGY1-2), senior residents (PGY3+), and attending surgeons from a single surgical department. ChatGPT-4 will be prompted with the same scenarios. All participants will be instructed to complete the cases without using external resources such as AI tools or internet searches, relying solely on their clinical knowledge.

Statistical analysis will compare performance across groups using non-parametric tests (e.g., Wilcoxon rank sum).

Expected Outcomes:

The study hypothesizes that ChatGPT-4 will perform at a level comparable to senior residents or attending surgeons and outperform junior residents in decision-making. If confirmed, these results could support the safe use of ChatGPT-4 as a training aid for junior surgical residents, potentially improving educational outcomes and clinical reasoning skills.

Significance:

This study will provide novel insight into the role of AI in surgical education. By rigorously comparing ChatGPT-4's decision-making capabilities to that of human surgeons at various levels, the study hopes to define its utility, limitations, and appropriate use in residency training programs.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Actively enrolled or employed in the general surgery residency or department at the participating institution
  • Willingness to participate and complete all clinical case scenarios
  • Consent to participate in the study

Exclusion criteria

  • Incomplete responses
  • Use of external assistance (e.g., internet search, AI tools) when answering scenarios, as self-reported in instructions

Treatment and study plan

Clinical Cases

Other

Seven clinical cases that have to be analysed

Primary outcomes

  1. Proportion of correct responses

    Time frame: Baseline

    Binary outcome (correct vs. incorrect decision)

Secondary outcomes

  1. Comparison of accuracy across experience levels

    Time frame: Baseline

    Proportion of correct responses by group: Junior residents, Senior residents, Attending surgeons, ChatGPT-4

  2. Confidence level

    Time frame: Baseline

    Participants and ChatGPT are asked to rate how confident they feel in their answer (1-5 Likert scale, where 1 means no confident and 5 very confident)

  3. Percentage of use of AI for clinical cases evaluation

    Time frame: Baseline

    Participants are asked if they use or not ChatGPT in their clinical activity

Study contacts

Contact information is provided by the study sponsor or research team.

Manuela Mastronardi

CONTACT

[email protected]

0403994152

Sponsors and collaborators

Lead sponsor

Ospedali Riuniti Trieste

Other

Registry information

Official study title

Evaluating ChatGPT-4 as a Decision-Making Support Tool for Surgical Trainees

Acronym: EDuCATe

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Apr 10, 2025
Registry last updated
Apr 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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