Evaluating Cardiovascular Phenotypes Using Induced Pluripotent Stem Cells

This research is being done to understand how changes in DNA may put people at risk for developing coronary artery disease. Stem cells will be made using cells from blood and/or skin biopsy samples. We are trying to understand which specific changes in DNA negatively impact a person's health.

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Key information

Conditions

Coronary Artery Disease Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Scripps Translational Science Institute

La Jolla, California, 92037, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Cases:

Previously enrolled in the CAD module of the Genebank at Scripps Clinic Registry
Eligible to have their blood drawn
Be reliable, cooperative and willing to comply with all protocol-specified procedures
Able to understand and grant informed consent

Controls:

Previously enrolled in the Healthy Elderly Active Longevity (HEAL) Cohort
Eligible to have their blood drawn
Be reliable, cooperative and willing to comply with all protocol-specified procedures
Able to understand and grant informed consent

Exclusion criteria

Unwilling or unable to grant informed consent.
Have a significant medical condition that in the Investigator's opinion may interfere with subject's study participation.

Treatment and study plan

Primary outcomes

iPSC development

Time frame: five years

Develop methods of iPSC generation from patients with genomic risk.

Sponsors and collaborators

Lead sponsor

Scripps Translational Science Institute

Other

Registry information

Acronym: iPSC

Important dates

Study start: 2012
Primary completion: 2025
Study completion: 2030
First posted: Jan 25, 2012
Registry last updated: Jan 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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