Evaluate the Safety and Efficacy of HL-1186 Tablet for Postoperative Pain Management in Abdominal Surgery

Inclusion criteria

• 18 years old ≤ age ≤ 75 years old, gender is not limited.
• 18 kg/m2 ≤ Body Mass Index (BMI) ≤ 30kg/m2.
• Scheduled to undergo abdominal surgeries under general anesthesia.
• Able to understand the research process and the use of pain scales, and communicate effectively with researchers.

Exclusion criteria

• Prior history of surgery at the same site, and this may affect pain perception at the surgical site per investigator's judgments.
• Allergy to any component of the investigational product, to perioperative anesthetic/analgesic/antiemetic agents, or to ≥3 substance allergies.
• Unstable angina, myocardial infarction, severe arrhythmias (e.g., third-degree atrioventricular block), New York Heart Association (NYHA) class III or higher cardiac function, recurrent asthma, etc., within screen period, and deemed ineligible per investigator's judgments.
• High bleeding risk conditions: Congenital bleeding disorders (e.g., hemophilia), platelet function abnormalities (e.g., idiopathic thrombocytopenic purpura, disseminated intravascular coagulation, congenital platelet function abnormalities), active bleeding, etc., and deemed ineligible per investigator's judgments.
• For female participants: Pregnant or lactating (within 1 year postpartum).
• Participants with childbearing potential planning conception/sperm/egg donation within 6 months post-treatment, or unwilling to use effective contraception (abstinence, barrier methods, oral contraceptives, intrauterine device, or sterilization).
• Judgment by the investigator that the participant should not enter the study due to other conditions.