Evaluate Advanced Pneumatic Compression Device With Revised Compression Programming for Lymphedema Treatment

Inclusion criteria

• 18 years of age or older
• A diagnosis of active lower extremity lymphedema, as assessed by medical history
• Participant is a candidate for APCD treatment per the Flexitouch Plus indications for use
• Must be able to provide informed consent prior to study participation
• Willing and able to comply with the study protocol requirements and all study-related visit requirements

Exclusion criteria

• Heart failure (acute pulmonary edema, decompensated acute heart failure)
• Acute venous disease (acute thrombophlebitis, acute deep venous thrombosis, acute pulmonary embolism)
• Severe peripheral artery disease (critical limb ischemia, including ischemic rest pain, arterial wounds or gangrene)
• Active skin or limb infection/inflammatory disease (acute cellulitis, other uncontrolled skin or untreated inflammatory skin disease) on the trunk or lower extremities
• Active cancer or metastasis in the lower extremity lymphatic watersheds
• Eczema, rash, scarring, or extensive tattoos at imaging sites
• Participant is pregnant or trying to become pregnant
• Participants with a history of allergy to iodides, who may be susceptible to iodine present in ICG formulation
• Patients exhibiting Grade 3 or higher on the CTCAE v6.0 superficial soft tissue fibrosis scale
• Body Mass Index (BMI) ≥40
• Participants unable to recline on their backs for up to 60 consecutive minutes and walk in place or tolerate assisted lower extremity movement for 5 minutes