European Transfusion Practice and Outcome Study

The aim of the ETPOS study is to describe differences in transfusion habits throughout Europe and to correlate these habits to perioperative outcome parameters. Special focus is put on the number of PRBCs (packed red blood cells) transfused and the ratio of PRBCs to other blood products or coagulation factors in the operating room. Furthermore the motivation of physicians to transfuse PRBC and blood products in the operating room will be investigated.

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Key information

Conditions

Surgery Anemia Behavior Blood Coagulation Disorders Erythrocyte Transfusion Habits Hematologic Diseases Hemic and Lymphatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University hospital "Merkur", Zagreb, Croatia

About this study

In European patients undergoing elective non-cardiac surgery receiving at least one PRBC(packed red blood cells) during their surgery it is proposed to:

Evaluate evidence of differences in the standard of peri-operative transfusion care in different healthcare systems within Europe, and the use of blood conserving techniques.

Evaluate the ratio of transfusion of PRBC to blood products in the operating room
Evaluate which factors determine transfusion of PRBC (is it patient's haemodynamics / haemoglobin threshold/ pressure from the surgeon / acute brisk bleeding / else) and blood products (ratio to PRBC / POC (point of care) monitoring/ per protocol/ else) in the operating room
Evaluate whether there are factors in transfusion therapy that are associated with outcome (in-hospital mortality and unplanned admission to ICU(Intensive Care Unit).)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients undergoing elective non-cardiac surgery commencing during the three-month period and who received at least one erythrocyte concentrate during their intra-operative stay.

Exclusion criteria

Age < 18 years
cardiothoracic surgery
emergency trauma patients

Treatment and study plan

Primary outcomes

Amount of PRBC and blood products and coagulation factors transfused

Time frame: The Time point at which outcome measure is assessed is during surgery at Day 0

Amount of packed red blood cells and blood products and coagulation factors: fresh frozen plasmas (FFPs), platelets (PTs) and tranexamic acid transfused

Secondary outcomes

Factors determining transfusion of PRBC and blood products in different regions of Europe

Time frame: The Time point at which outcome measure is assessed is during surgery at Day 0

Reasons for transfusion of PRBC(packed red blood cells)and blood products in different regions of Europe
30-day mortality

Time frame: The Time point at which outcome measure is assessed is at Day 30 after Surgery

Assesses on Day 30 whether patient is still alive or has died between day zero (Surgery) day 30 after surgery
Unplanned admission to the ICU

Time frame: The Time point at which outcome measure is assessed is at Day 30 after Surgery

Assesses on day 30 whether the patient had a Unplanned admission to the Intensive care unit(ICU) following surgery (day 0) until the day 30
Type and frequency of usage of blood conserving techniques

Time frame: The Time point at which outcome measure is assessed is at Day 0, on Surgery Day

Sponsors and collaborators

Lead sponsor

European Society of Anaesthesiology

Other

Registry information

Official study title

European Transfusion Practice and Outcome Study A Multi-central Evaluation of Standard of Transfusion Care and Clinical Outcome for Elective Surgical Patients. Observational Study.

Acronym: ETPOS

Important dates

Study start: 2013
Primary completion: 2013
Study completion: 2013
First posted: May 23, 2012
Registry last updated: May 1, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed