European Research Group on Outcomes of Surgical Treatment of Infective Endocarditis

The European Research Group on Outcomes of Surgical Treatment of Infective Endocarditis (ERGOSTE) is a nascent large surgical registry that would encompass most relevant aspects of IE in Europe in the contemporary era.

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Key information

Conditions

Infective Endocarditis (IE) Cardiovascular Diseases Endocarditis Heart Diseases Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Cardiac Surgery Unit - ASUGI

Trieste, TRIESTE, 34151, Italy

About this study

ERGOSTE, Purposes:

To create a European multicenter retrospective database including a large number of patients undergoing surgical treatment for infective endocarditis (IE).
To perform epidemiologic analyses of IE-patients and involved pathogens.
To find independent predictors of early post-operative death.
To test ALL the scoring systems specifically developed to predict early death after surgery for infective endocarditis.
To devise a specific risk score for early postoperative death.
To explore early and late outcomes of these very difficult patients in order to establish optimal indications, techniques and timing of surgery.
To carry out a number of sub-analyses concerning the demographic parameters and variable clinical presentation of patients, type and severity of cardiac structural involvement, adopted valve prostheses and surgical techniques, and different involved microbiologic agents.
To lay experiential foundations of a prospective database on the topic.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients undergoing cardiac surgery due to infective endocarditis

Exclusion criteria

Patients under 18 years

Treatment and study plan

Primary outcomes

Early post-operative mortality

Time frame: Mortality at 1 year after surgery

Sponsors and collaborators

Lead sponsor

Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI)

Other

Registry information

Official study title

European Research Group on Outcomes of Surgical Treatment of Infective Endocarditis (ERGOSTE)

Acronym: ERGOSTE

Important dates

Study start: 2025
Primary completion: 2025
Study completion: 2025
First posted: Aug 7, 2025
Registry last updated: Aug 7, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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