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NCT Number: NCT06935045

Ethanol Consumption in the Heat

Climate change has significantly increased the earth's average surface temperature and heat waves have been predicted to increase in frequency, intensity and duration. Extreme heat events have increased the susceptibility to heat-related illnesses, such as heat exhaustion, heat stroke or death. Heat health action plans have been designed to advertise cooling behaviours to mitigate physiological strain. Heat health action plans suggest avoiding alcohol consumption during extreme heat as it may increase dehydration and impair behavioural or physiological temperature regulation and thermal perception. Regardless of these messages, alcohol sales continue to remain high during the summer months year after year, and 1/5 of adults identify alcohol as a hydration strategy during extreme heat events. A recent scoping review investigating the effects of alcohol and heat has demonstrated that acute alcohol consumption does not negatively influence thermoregulation, hydration, or hormone markers of fluid balance in the heat compared to a control fluid (https://doi.org/10.1186/s12940-024-01113-y). Further, alcohol consumption may elicit sex- and age-specific alterations in physiological and perceptual responses, neither of which have been explored.

Therefore, this study aims to comprehensively evaluate how alcohol consumption systematically alters physiological responses and perceptions during conditions similar to those experienced indoors during extreme heat events in younger and older adults.

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Key information

Age range

19 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Lakehead University

Thunder Bay, Ontario, P7B 5E1, Canada

Location status: Recruiting

Location contact

Amy Brough, BHK

SUB_INVESTIGATOR

Georgia Chaseling, PhD

SUB_INVESTIGATOR

KarLee Lefebvre, BHK

SUB_INVESTIGATOR

Nathan Morris, PhD

SUB_INVESTIGATOR

Nicholas Ravanelli, PhD

CONTACT

[email protected]

8073438010

Taryn Klarner, BHK

SUB_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or Female above the age of 19
  • Able to provide informed consent

Exclusion criteria

  • History of cardiovascular disease, cancer, type 1 or 2 diabetes, chronic obstructive pulmonary disorder, cystic fibrosis, or alcohol addiction or dependence
  • Been hospitalized due to COVID-19
  • Pregnant/Breastfeeding
  • Scoring an eight or above on the Alcohol Use Disorders Identification Test (AUDIT)

Treatment and study plan

Placebo Beverage

Drug

Participants rest in a climate controlled room maintained at 40°C and 30%RH for 120 minutes follow placebo beverage consumption (180 minutes total).

Alcohol (Ethanol)

Drug

Participants rest in a climate controlled room maintained at 40°C and 30%RH for 120 minutes follow alcoholic beverage consumption (180 minutes total).

Primary outcomes

  1. Heart Rate

    Time frame: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

    3-lead electrocardiogram

  2. Skin Temperature

    Time frame: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

    Mean skin (4 sites)

  3. Core Temperature

    Time frame: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

    measured rectally

  4. Blood Pressure

    Time frame: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

    ECG-gated blood pressure cuff

  5. Heart Rate Variability

    Time frame: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

  6. Arrythmia presence

    Time frame: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

  7. Whole-body Sweat Loss

    Time frame: mass measured at baseline and end heat stress.

    Difference in mass from baseline to end heat stress

  8. Postural Sway via the Romberg Test

    Time frame: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

    The total movement of the body around the center of mass with feet together

  9. Skin Blood Flow

    Time frame: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

  10. Urine Output

    Time frame: Total urine output (e.g. volume) from baseline to immediately following 120 minutes of heat stress

  11. ASHRAE seven-point thermal sensation scale

    Time frame: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

  12. 5-Point Thermal Comfort Scale

    Time frame: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

    Thermal comfort scale with 1- comfortable and 5 - very uncomfortable

Secondary outcomes

  1. Subjective Blood Alcohol Concentration (visual analog scale 0.0 - 0.20)

    Time frame: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

    Visual analog scale with left and right anchors of 0.0 and 0.20, respectively, with markers every 0.005 increment

  2. Blood Alcohol Concentration

    Time frame: measured at baseline (pre drink), and every 30 minutes following consumption (up to 120 minutes).

    Measured using a police grade portable breathalyzer

Study contacts

Contact information is provided by the study sponsor or research team.

Nicholas Ravanelli, PhD

CONTACT

[email protected]

18073438010

Sponsors and collaborators

Lead sponsor

Lakehead University

Other

Registry information

Official study title

Evaluating How Alcohol Impacts Physiological Responses and Perception During Heat Exposure

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Apr 18, 2025
Registry last updated
Apr 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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